Nucleic acid amplification with DNA-dependant RNA polymerase activity of RNA replicases
The present invention entails methods and kits for carrying them out based on the discovery that an RNA replicase, such as Qbeta replicase, has DNA-dependent RNA polymerase ("DDRP") activity with nucleic acid segments, including DNA segments and DNA:RNA chimeric segments, which comprise a...
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| creator | RICHARD A. MARTINELLI RANDALL L. DIMOND JOHN E. MONAHAN JAMES W. SCHUMM GEOFFREY R. HUDSON MARK A. MAFFITT LEOPOLDO G. MENDOZA JAMES R HARTNETT CHRISTOPHER L. JONES EDWARD E. PAHUSKI STEVEN J. EKENBERG KATHERINE M. MILLER |
| description | The present invention entails methods and kits for carrying them out based on the discovery that an RNA replicase, such as Qbeta replicase, has DNA-dependent RNA polymerase ("DDRP") activity with nucleic acid segments, including DNA segments and DNA:RNA chimeric segments, which comprise a 2'-deoxyribonucleotide or an analog thereof and which have sequences of RNAs that are autocatalytically replicatable by the replicase. |
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PAHUSKI</au><au>STEVEN J. EKENBERG</au><au>KATHERINE M. MILLER</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Nucleic acid amplification with DNA-dependant RNA polymerase activity of RNA replicases</title><date>1998-07-16</date><risdate>1998</risdate><abstract>The present invention entails methods and kits for carrying them out based on the discovery that an RNA replicase, such as Qbeta replicase, has DNA-dependent RNA polymerase ("DDRP") activity with nucleic acid segments, including DNA segments and DNA:RNA chimeric segments, which comprise a 2'-deoxyribonucleotide or an analog thereof and which have sequences of RNAs that are autocatalytically replicatable by the replicase.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | Nucleic acid amplification with DNA-dependant RNA polymerase activity of RNA replicases |
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