Ligand precursors for incorporation into peptides

Compositions and methods of incorporating ligand precursors and ligands at any location within a peptide during peptide synthesis are disclosed. Derivatives of 2,4,5-triaminopentanoic acid and gamma -aminoglutamic acid are selectively incorporated into the peptide during solid phase or liquid phase...

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Hauptverfasser: T. JEFFREY DUNN, ANANTHACHARI SRINIVASAN
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ANANTHACHARI SRINIVASAN
description Compositions and methods of incorporating ligand precursors and ligands at any location within a peptide during peptide synthesis are disclosed. Derivatives of 2,4,5-triaminopentanoic acid and gamma -aminoglutamic acid are selectively incorporated into the peptide during solid phase or liquid phase synthesis, depending upon the choice of protecting groups. Ligand synthesis may then be completed at a later time to produce N3S, N2S2, and EDTA type chelating agents.
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Derivatives of 2,4,5-triaminopentanoic acid and gamma -aminoglutamic acid are selectively incorporated into the peptide during solid phase or liquid phase synthesis, depending upon the choice of protecting groups. 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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title Ligand precursors for incorporation into peptides
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