1,2,3,6-tetrahydropyridine derivatives useful for improving cerebal blood circulation

The present invention relates to novel 1,2,3,6-tetrahydropyridine derivatives of the general formula (I) - wherein R stands for hydrogen or an alkyl group, X stands for an unsubstituted phenyl or benzyl group or for a phenyl or benzyl group substituted with a halogen atom, Y stands for hydrogen or halogen or a trifluoro-methyl group - as well as enantiomers acid addition salts thereof. The invention further extends to pharmaceutical compositions containing said compounds as active ingredient mainly for improving cerebral blood circulation and antihypoxic activity. The 1,2,3,6-tetrahydropyridine derivatives of the general formula (I) are prepared by treating an oxo derivative of the general formula (II) wherein R, X and Y are as given above in an organic solvent by a reducing agent and reacting the obtained 1,2,3,6-tetrahydropyridine derivative of the general formula (I), wherein R, X and Y are as given above, with a mineral or organic acid and converting the same, if desired, to an acid addition salt.