METHOD OF TREATING HAEMATOLOGIC DISEASES AND PHARMACEUTICAL COMPOSITIONS TO BE USED THEREFOR

The present invention relates to a method of treating hematopoietic diseases in a warm-blooded living being by administration of a composition comprising at least one compound of the general formula wherein R1 is a phenyl group, a C1-C16 alkyl group, a C6-C12 (bridged) cycloalkyl group, a cyclohexadienyl group, a styryl group, a phenyl(C1-C4)alkyl group, an N-oxypyridyl group or a heteroaryl group having 1 or 2 nitrogen atoms in its nucleus, which groups may be substituted with one or more substituents selected from the group consisting of halogen, C1-C6 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy, C1-C4 haloalkoxy, C1-C4 alkylthio, C1-C4 haloalkylthio, nitro, hydroxy, C1-C5 alkanoyloxy and amino, which amino group may be substituted with a C2-C5 alkanoyl group or with 1 or 2 C1-C4 alkyl groups which, together with the amino N, may form a heterocyclic ring; X is an oxygen atom or a sulphur atom; R3 is a hydrogen atom, a C1-C4 alkyl group or a C2-C5 alkoxyalkyl group; Y is an oxygen atom or a sulphur atom; R4 is a hydrogen atom or a C1-C4 alkyl group; n is 0 or 1; and R2 is a hydrogen atom, a C1-C6 alkyl group, a phenyl group, a C6-C12 (bridged) cycloalkyl group, a phenyl(C1-C4)alkyl group or a heterocyclic group having 1-3 hetero atoms selected from N, O and S in its nucleus, which phenyl group, cycloalkyl group, phenylalkyl group and heterocyclic group may be substituted with one or more substituents selected from the group consisting of halogen, C1-C6 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy, a C1-C4 haloalkoxy, C1-C4 alkylthio, C1-C4 haloalkylthio, C1-C4 alkylsulphinyl, C1-C4 haloalkylsulphinyl, C1-C4 alkylsulphonyl, C1-C4 haloalkylsulphonyl, optionally substituted C3-C12 cycloalkyl, optionally substituted C3-C12 cycloalkoxy, nitro, hydroxy, cyano, C2-C5 alkylcarbonyl, C2-C5 alkoxycarbonyl, optionally substituted benzoyl, optionally substituted phenoxy, optionally substituted phenyl(C1-C4)alkoxy, optionally substituted heteroaryloxy having 1 or 2 heteroatoms in its aromatic nucleus selected from N, O and S, and amino, which amino group may be substituted with a C2-C5 alkanoyl group or with 1 or 2 C1-C4 alkyl groups which, together with the amino N, may form a heterocyclic ring, which ring may comprise an additional N and may be substituted in its turn; or wherein two of the said substituents together constitute a C1-C3 alkylenedioxy group or haloalkylenedioxy group.