ANTICHOLINERGIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHOD OF TREATMENT
Esters, of polar acidic metabolites of atropine, siopolamine etc. of formula (I) and having anticholinergic or mydriatic properties are new. where R' = esterification residue of a pharmaceutically acceptable, non-toxic, opt. substd. cyclic or opt.branched 1-8C alcohol (R'-OH) such that COO...
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| creator | RICHARD H. HAMMER NICHOLAS S. BODOR |
| description | Esters, of polar acidic metabolites of atropine, siopolamine etc. of formula (I) and having anticholinergic or mydriatic properties are new. where R' = esterification residue of a pharmaceutically acceptable, non-toxic, opt. substd. cyclic or opt.branched 1-8C alcohol (R'-OH) such that COOR1 is metabolically hydrolysable to R'-OH and a non-toxic metabolite of (I) following admin. R2 =opt. substd. aryl, cycloalkyl or alkyl of 1-8C; R3 = H or R2; n = 0-4; X = -O-CO-; -NR8-CO-, -CO-, -CR9R10-, -S-, -O- or -NH-; R8 = H or opt. branched 1-5C alkyl; R9, R10 = H or 1-5C alkyl; m = 0-4; R4 = bicyclic amine gp. formula (a), (b) or (c), -NR6R6, -NR5R6R7(+), o, m- or p-substd. alkyl pyridine, or non-toxic quat. ammonium salt gp. (-N(B)3(+)X(-)); R5, R6, R7 = 1-5C aklyl; X(-)=anion. |
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BODOR</creatorcontrib><description>Esters, of polar acidic metabolites of atropine, siopolamine etc. of formula (I) and having anticholinergic or mydriatic properties are new. where R' = esterification residue of a pharmaceutically acceptable, non-toxic, opt. substd. cyclic or opt.branched 1-8C alcohol (R'-OH) such that COOR1 is metabolically hydrolysable to R'-OH and a non-toxic metabolite of (I) following admin. R2 =opt. substd. aryl, cycloalkyl or alkyl of 1-8C; R3 = H or R2; n = 0-4; X = -O-CO-; -NR8-CO-, -CO-, -CR9R10-, -S-, -O- or -NH-; R8 = H or opt. branched 1-5C alkyl; R9, R10 = H or 1-5C alkyl; m = 0-4; R4 = bicyclic amine gp. formula (a), (b) or (c), -NR6R6, -NR5R6R7(+), o, m- or p-substd. alkyl pyridine, or non-toxic quat. ammonium salt gp. (-N(B)3(+)X(-)); R5, R6, R7 = 1-5C aklyl; X(-)=anion.</description><edition>4</edition><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1990</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19900329&DB=EPODOC&CC=AU&NR=595307B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19900329&DB=EPODOC&CC=AU&NR=595307B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>RICHARD H. HAMMER</creatorcontrib><creatorcontrib>NICHOLAS S. BODOR</creatorcontrib><title>ANTICHOLINERGIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHOD OF TREATMENT</title><description>Esters, of polar acidic metabolites of atropine, siopolamine etc. of formula (I) and having anticholinergic or mydriatic properties are new. where R' = esterification residue of a pharmaceutically acceptable, non-toxic, opt. substd. cyclic or opt.branched 1-8C alcohol (R'-OH) such that COOR1 is metabolically hydrolysable to R'-OH and a non-toxic metabolite of (I) following admin. R2 =opt. substd. aryl, cycloalkyl or alkyl of 1-8C; R3 = H or R2; n = 0-4; X = -O-CO-; -NR8-CO-, -CO-, -CR9R10-, -S-, -O- or -NH-; R8 = H or opt. branched 1-5C alkyl; R9, R10 = H or 1-5C alkyl; m = 0-4; R4 = bicyclic amine gp. formula (a), (b) or (c), -NR6R6, -NR5R6R7(+), o, m- or p-substd. alkyl pyridine, or non-toxic quat. ammonium salt gp. (-N(B)3(+)X(-)); R5, R6, R7 = 1-5C aklyl; X(-)=anion.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1990</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPBz9AvxdPbw9_H0cw1y93RWcPb3DfAP9XMJ1lEI8HAM8nV0dg0FqnD0gcgEe4Z4-vsFKzj6uSj4uoZ4-Lso-LsphAS5Oob4uvqF8DCwpiXmFKfyQmluBgU31xBnD93Ugvz41OKCxOTUvNSSeMdQU0tTYwNzJycjYyKUAADwUS6f</recordid><startdate>19900329</startdate><enddate>19900329</enddate><creator>RICHARD H. HAMMER</creator><creator>NICHOLAS S. BODOR</creator><scope>EVB</scope></search><sort><creationdate>19900329</creationdate><title>ANTICHOLINERGIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHOD OF TREATMENT</title><author>RICHARD H. HAMMER ; NICHOLAS S. BODOR</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_AU595307BB23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1990</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>RICHARD H. HAMMER</creatorcontrib><creatorcontrib>NICHOLAS S. BODOR</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>RICHARD H. HAMMER</au><au>NICHOLAS S. BODOR</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ANTICHOLINERGIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHOD OF TREATMENT</title><date>1990-03-29</date><risdate>1990</risdate><abstract>Esters, of polar acidic metabolites of atropine, siopolamine etc. of formula (I) and having anticholinergic or mydriatic properties are new. where R' = esterification residue of a pharmaceutically acceptable, non-toxic, opt. substd. cyclic or opt.branched 1-8C alcohol (R'-OH) such that COOR1 is metabolically hydrolysable to R'-OH and a non-toxic metabolite of (I) following admin. R2 =opt. substd. aryl, cycloalkyl or alkyl of 1-8C; R3 = H or R2; n = 0-4; X = -O-CO-; -NR8-CO-, -CO-, -CR9R10-, -S-, -O- or -NH-; R8 = H or opt. branched 1-5C alkyl; R9, R10 = H or 1-5C alkyl; m = 0-4; R4 = bicyclic amine gp. formula (a), (b) or (c), -NR6R6, -NR5R6R7(+), o, m- or p-substd. alkyl pyridine, or non-toxic quat. ammonium salt gp. (-N(B)3(+)X(-)); R5, R6, R7 = 1-5C aklyl; X(-)=anion.</abstract><edition>4</edition><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | ANTICHOLINERGIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHOD OF TREATMENT |
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