DIASTEREOSELECTIVE REDUCTION OF 3-AMINO -1-BENZOXEPINE -5(2H)-ONE

DIASTEREOSELECTIVE REDUCTION OF 3-AMINO -1-BENZOXEPINE -5(2H)-ONE

A process for producing cis-2,3,4,5-tetrahydro-3-amino-1-benzoxepin-5-ols in which 3-amino-1-benzoxepin-5(2H)-ones are diastereoselectively reduced in a single stage by catalytic hydrogenation in the presence of a platinum oxide catalyst and an equivalent amount of an acid in a polar protic solvent,...

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Hauptverfasser: HEINRICH WILHELM OHLENDORF, UWE MATZEL
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Sprache:eng
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator HEINRICH WILHELM OHLENDORF
UWE MATZEL
description A process for producing cis-2,3,4,5-tetrahydro-3-amino-1-benzoxepin-5-ols in which 3-amino-1-benzoxepin-5(2H)-ones are diastereoselectively reduced in a single stage by catalytic hydrogenation in the presence of a platinum oxide catalyst and an equivalent amount of an acid in a polar protic solvent, or by reaction with a borane/amine complex in an aprotic solvent, optionally in the presence of an added lower aliphatic carboxylic acid.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title DIASTEREOSELECTIVE REDUCTION OF 3-AMINO -1-BENZOXEPINE -5(2H)-ONE
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