BETA-CARBOLINE DERIVATIVES
Substituted beta -carbolines of the formula I in which R denotes the 5-oxadiazolyl radical where R' has the meaning C1-3-alkyl and C3-C6-alkyl and the alkoxycarbonyl radical -COOR'' where R'' has the meaning C1-4-alkyl, R denotes hydrogen, methyl, ethyl and methoxymethyl and...
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| creator | DR MOGENS ENGELSTOFT DR DIETER SEIDELMANN DR RALPH SCHMIECHEN DR CLAUS THYCO BRAESTRUP DR ANDREAS HUTH DR DIETER RAHTZ |
| description | Substituted beta -carbolines of the formula I
in which
R denotes the 5-oxadiazolyl radical
where R' has the meaning C1-3-alkyl and C3-C6-alkyl and
the alkoxycarbonyl radical -COOR'' where R'' has the meaning C1-4-alkyl,
R denotes hydrogen, methyl, ethyl and methoxymethyl and
R denotes the aryl radical
and the aralkyl radical
where X has the meaning C1-12-alkyl, it being possible for the alkyl radical to be straight-chain, branched, saturated or unsaturated and for a CH2 group to be substituted by a carbonyl group, and where R''' has the meaning fluorine, chlorine, bromine or iodine, C1-3-alkyl, C1-3-alkoxy, C1-5-acyloxy, phenyl, C2-5-alkylenedioxy, trifluoromethyl, nitrilo, nitro or an amino group -NRR where
R and R have the meaning hydrogen, C1-3-alkyl, C1-5-acyl or phenyl, it being possible for R and R to be identical or different and to form a 3-6-membered hetero ring system together with the amino nitrogen atom,
it being possible for the substituent R''' to occur once or more on the aryl radical in an identical or different manner, and a process for their preparation are described.
The compounds have an action on the central nervous system and are thus suitable as psychopharmaceuticals. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_AU575566BB2</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>AU575566BB2</sourcerecordid><originalsourceid>FETCH-epo_espacenet_AU575566BB23</originalsourceid><addsrcrecordid>eNrjZJBycg1x1HV2DHLy9_H0c1VwcQ3yDHMM8QxzDeZhYE1LzClO5YXS3AwKbq4hzh66qQX58anFBYnJqXmpJfGOoabmpqZmZk5ORsZEKAEA-I4gFQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>BETA-CARBOLINE DERIVATIVES</title><source>esp@cenet</source><creator>DR MOGENS ENGELSTOFT ; DR DIETER SEIDELMANN ; DR RALPH SCHMIECHEN ; DR CLAUS THYCO BRAESTRUP ; DR ANDREAS HUTH ; DR DIETER RAHTZ</creator><creatorcontrib>DR MOGENS ENGELSTOFT ; DR DIETER SEIDELMANN ; DR RALPH SCHMIECHEN ; DR CLAUS THYCO BRAESTRUP ; DR ANDREAS HUTH ; DR DIETER RAHTZ</creatorcontrib><description>Substituted beta -carbolines of the formula I
in which
R denotes the 5-oxadiazolyl radical
where R' has the meaning C1-3-alkyl and C3-C6-alkyl and
the alkoxycarbonyl radical -COOR'' where R'' has the meaning C1-4-alkyl,
R denotes hydrogen, methyl, ethyl and methoxymethyl and
R denotes the aryl radical
and the aralkyl radical
where X has the meaning C1-12-alkyl, it being possible for the alkyl radical to be straight-chain, branched, saturated or unsaturated and for a CH2 group to be substituted by a carbonyl group, and where R''' has the meaning fluorine, chlorine, bromine or iodine, C1-3-alkyl, C1-3-alkoxy, C1-5-acyloxy, phenyl, C2-5-alkylenedioxy, trifluoromethyl, nitrilo, nitro or an amino group -NRR where
R and R have the meaning hydrogen, C1-3-alkyl, C1-5-acyl or phenyl, it being possible for R and R to be identical or different and to form a 3-6-membered hetero ring system together with the amino nitrogen atom,
it being possible for the substituent R''' to occur once or more on the aryl radical in an identical or different manner, and a process for their preparation are described.
The compounds have an action on the central nervous system and are thus suitable as psychopharmaceuticals.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1988</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19880804&DB=EPODOC&CC=AU&NR=575566B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19880804&DB=EPODOC&CC=AU&NR=575566B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>DR MOGENS ENGELSTOFT</creatorcontrib><creatorcontrib>DR DIETER SEIDELMANN</creatorcontrib><creatorcontrib>DR RALPH SCHMIECHEN</creatorcontrib><creatorcontrib>DR CLAUS THYCO BRAESTRUP</creatorcontrib><creatorcontrib>DR ANDREAS HUTH</creatorcontrib><creatorcontrib>DR DIETER RAHTZ</creatorcontrib><title>BETA-CARBOLINE DERIVATIVES</title><description>Substituted beta -carbolines of the formula I
in which
R denotes the 5-oxadiazolyl radical
where R' has the meaning C1-3-alkyl and C3-C6-alkyl and
the alkoxycarbonyl radical -COOR'' where R'' has the meaning C1-4-alkyl,
R denotes hydrogen, methyl, ethyl and methoxymethyl and
R denotes the aryl radical
and the aralkyl radical
where X has the meaning C1-12-alkyl, it being possible for the alkyl radical to be straight-chain, branched, saturated or unsaturated and for a CH2 group to be substituted by a carbonyl group, and where R''' has the meaning fluorine, chlorine, bromine or iodine, C1-3-alkyl, C1-3-alkoxy, C1-5-acyloxy, phenyl, C2-5-alkylenedioxy, trifluoromethyl, nitrilo, nitro or an amino group -NRR where
R and R have the meaning hydrogen, C1-3-alkyl, C1-5-acyl or phenyl, it being possible for R and R to be identical or different and to form a 3-6-membered hetero ring system together with the amino nitrogen atom,
it being possible for the substituent R''' to occur once or more on the aryl radical in an identical or different manner, and a process for their preparation are described.
The compounds have an action on the central nervous system and are thus suitable as psychopharmaceuticals.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1988</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZJBycg1x1HV2DHLy9_H0c1VwcQ3yDHMM8QxzDeZhYE1LzClO5YXS3AwKbq4hzh66qQX58anFBYnJqXmpJfGOoabmpqZmZk5ORsZEKAEA-I4gFQ</recordid><startdate>19880804</startdate><enddate>19880804</enddate><creator>DR MOGENS ENGELSTOFT</creator><creator>DR DIETER SEIDELMANN</creator><creator>DR RALPH SCHMIECHEN</creator><creator>DR CLAUS THYCO BRAESTRUP</creator><creator>DR ANDREAS HUTH</creator><creator>DR DIETER RAHTZ</creator><scope>EVB</scope></search><sort><creationdate>19880804</creationdate><title>BETA-CARBOLINE DERIVATIVES</title><author>DR MOGENS ENGELSTOFT ; DR DIETER SEIDELMANN ; DR RALPH SCHMIECHEN ; DR CLAUS THYCO BRAESTRUP ; DR ANDREAS HUTH ; DR DIETER RAHTZ</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_AU575566BB23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1988</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>DR MOGENS ENGELSTOFT</creatorcontrib><creatorcontrib>DR DIETER SEIDELMANN</creatorcontrib><creatorcontrib>DR RALPH SCHMIECHEN</creatorcontrib><creatorcontrib>DR CLAUS THYCO BRAESTRUP</creatorcontrib><creatorcontrib>DR ANDREAS HUTH</creatorcontrib><creatorcontrib>DR DIETER RAHTZ</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>DR MOGENS ENGELSTOFT</au><au>DR DIETER SEIDELMANN</au><au>DR RALPH SCHMIECHEN</au><au>DR CLAUS THYCO BRAESTRUP</au><au>DR ANDREAS HUTH</au><au>DR DIETER RAHTZ</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>BETA-CARBOLINE DERIVATIVES</title><date>1988-08-04</date><risdate>1988</risdate><abstract>Substituted beta -carbolines of the formula I
in which
R denotes the 5-oxadiazolyl radical
where R' has the meaning C1-3-alkyl and C3-C6-alkyl and
the alkoxycarbonyl radical -COOR'' where R'' has the meaning C1-4-alkyl,
R denotes hydrogen, methyl, ethyl and methoxymethyl and
R denotes the aryl radical
and the aralkyl radical
where X has the meaning C1-12-alkyl, it being possible for the alkyl radical to be straight-chain, branched, saturated or unsaturated and for a CH2 group to be substituted by a carbonyl group, and where R''' has the meaning fluorine, chlorine, bromine or iodine, C1-3-alkyl, C1-3-alkoxy, C1-5-acyloxy, phenyl, C2-5-alkylenedioxy, trifluoromethyl, nitrilo, nitro or an amino group -NRR where
R and R have the meaning hydrogen, C1-3-alkyl, C1-5-acyl or phenyl, it being possible for R and R to be identical or different and to form a 3-6-membered hetero ring system together with the amino nitrogen atom,
it being possible for the substituent R''' to occur once or more on the aryl radical in an identical or different manner, and a process for their preparation are described.
The compounds have an action on the central nervous system and are thus suitable as psychopharmaceuticals.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | BETA-CARBOLINE DERIVATIVES |
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