DIOXOPIPERAZINE DERIVATIVES

DIOXOPIPERAZINE DERIVATIVES

1-Benzyl-4-[4-(2-pyrimidinylamino)benzyl]- 2,3-dioxopiperazine derivatives represented by the formula: wherein R is optionally substituted hydrocarbyl or acyl, R is H or alkyl and X is O or S, and salts thereof have an excellent carcinostatic activity but a low toxicity. Therefore, said compounds ar...

Ausführliche Beschreibung

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Hauptverfasser: SUMIKO KISHIMOTO, HISATSUGU TSUDA, JOJI NAKANO, TAKAKO HORI, RYUKO TAKENO, JUN NITTA, YASUO KIBA, CHOSAKU YOSHIDA, SHOHACHI MURAKAMI, ISAMU SAIKAWA
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:1-Benzyl-4-[4-(2-pyrimidinylamino)benzyl]- 2,3-dioxopiperazine derivatives represented by the formula: wherein R is optionally substituted hydrocarbyl or acyl, R is H or alkyl and X is O or S, and salts thereof have an excellent carcinostatic activity but a low toxicity. Therefore, said compounds are useful as medicines and also as intermediates.