INTERFURANYLENE-PROSTACYCLIN DERIVATIVES
The invention relates to novel interfuranylene-prosta-cyclin derivatives of the general formula (I) wherein R stands for hydrogen or a straight or branched chain C16 alkyl group, an inorganic cation or for the protonated form of a base containing an amino group; R stands for hydrogen, a C1-4 alk...
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| creator | PAL HADHAZY GYORGY DORMAN SANDOR VIRAG PETER KORMOCZI ISTVAN TOMOSKOZY JOZSEF IVANICS KAROLY KANAY ISTVAN STADLER MIKLOS KISS GEZA GALAMBOS GABOR KOVACS |
| description | The invention relates to novel interfuranylene-prosta-cyclin derivatives of the general formula (I)
wherein
R stands for hydrogen or a straight or branched chain C16 alkyl group, an inorganic cation or for the protonated form of a base containing an amino group;
R stands for hydrogen, a C1-4 alkanoyl or benzoyl group, a monosubstituted benzoyl, trialkylsilyl or an alkoxy-alkyl group;
R stands for a straight or branched chain C1-6 alkyl group, a phenyl group optionally substituted by halogen or by a C1-4 alkyl group, a heteroaryl group optionally substituted by halogen or by a C1-4 alkyl group or a cycloalkyl group;
A stands for an ethylene or for a cis- or trans-vinylene or -C IDENTICAL C- group;
B means a chemical bond, a -CHR -, -CHR -CH2- or a -CH2-O- group: and
R means hydrogen or a C1-4 alkyl group.
The compounds of the formula (I) can be used therapeutically as platelet aggregation inhibiting, anti-thrombotic, hypotensive and anti-antherosclerotic agents; they are much more stable than the natural prostacyclin derivatives. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_AU5251486A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>AU5251486A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_AU5251486A3</originalsourceid><addsrcrecordid>eNrjZNDw9AtxDXILDXL0i_Rx9XPVDQjyDw5xdI509vH0U3BxDfIMcwzxDHMN5mFgTUvMKU7lhdLcDPJuriHOHrqpBfnxqcUFicmpeakl8Y6hpkamhiYWZo7GhFUAAMUWI_w</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>INTERFURANYLENE-PROSTACYCLIN DERIVATIVES</title><source>esp@cenet</source><creator>PAL HADHAZY ; GYORGY DORMAN ; SANDOR VIRAG ; PETER KORMOCZI ; ISTVAN TOMOSKOZY ; JOZSEF IVANICS ; KAROLY KANAY ; ISTVAN STADLER ; MIKLOS KISS ; GEZA GALAMBOS ; GABOR KOVACS</creator><creatorcontrib>PAL HADHAZY ; GYORGY DORMAN ; SANDOR VIRAG ; PETER KORMOCZI ; ISTVAN TOMOSKOZY ; JOZSEF IVANICS ; KAROLY KANAY ; ISTVAN STADLER ; MIKLOS KISS ; GEZA GALAMBOS ; GABOR KOVACS</creatorcontrib><description> The invention relates to novel interfuranylene-prosta-cyclin derivatives of the general formula (I)
wherein
R stands for hydrogen or a straight or branched chain C16 alkyl group, an inorganic cation or for the protonated form of a base containing an amino group;
R stands for hydrogen, a C1-4 alkanoyl or benzoyl group, a monosubstituted benzoyl, trialkylsilyl or an alkoxy-alkyl group;
R stands for a straight or branched chain C1-6 alkyl group, a phenyl group optionally substituted by halogen or by a C1-4 alkyl group, a heteroaryl group optionally substituted by halogen or by a C1-4 alkyl group or a cycloalkyl group;
A stands for an ethylene or for a cis- or trans-vinylene or -C IDENTICAL C- group;
B means a chemical bond, a -CHR -, -CHR -CH2- or a -CH2-O- group: and
R means hydrogen or a C1-4 alkyl group.
The compounds of the formula (I) can be used therapeutically as platelet aggregation inhibiting, anti-thrombotic, hypotensive and anti-antherosclerotic agents; they are much more stable than the natural prostacyclin derivatives.</description><edition>4</edition><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1986</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19860724&DB=EPODOC&CC=AU&NR=5251486A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19860724&DB=EPODOC&CC=AU&NR=5251486A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>PAL HADHAZY</creatorcontrib><creatorcontrib>GYORGY DORMAN</creatorcontrib><creatorcontrib>SANDOR VIRAG</creatorcontrib><creatorcontrib>PETER KORMOCZI</creatorcontrib><creatorcontrib>ISTVAN TOMOSKOZY</creatorcontrib><creatorcontrib>JOZSEF IVANICS</creatorcontrib><creatorcontrib>KAROLY KANAY</creatorcontrib><creatorcontrib>ISTVAN STADLER</creatorcontrib><creatorcontrib>MIKLOS KISS</creatorcontrib><creatorcontrib>GEZA GALAMBOS</creatorcontrib><creatorcontrib>GABOR KOVACS</creatorcontrib><title>INTERFURANYLENE-PROSTACYCLIN DERIVATIVES</title><description> The invention relates to novel interfuranylene-prosta-cyclin derivatives of the general formula (I)
wherein
R stands for hydrogen or a straight or branched chain C16 alkyl group, an inorganic cation or for the protonated form of a base containing an amino group;
R stands for hydrogen, a C1-4 alkanoyl or benzoyl group, a monosubstituted benzoyl, trialkylsilyl or an alkoxy-alkyl group;
R stands for a straight or branched chain C1-6 alkyl group, a phenyl group optionally substituted by halogen or by a C1-4 alkyl group, a heteroaryl group optionally substituted by halogen or by a C1-4 alkyl group or a cycloalkyl group;
A stands for an ethylene or for a cis- or trans-vinylene or -C IDENTICAL C- group;
B means a chemical bond, a -CHR -, -CHR -CH2- or a -CH2-O- group: and
R means hydrogen or a C1-4 alkyl group.
The compounds of the formula (I) can be used therapeutically as platelet aggregation inhibiting, anti-thrombotic, hypotensive and anti-antherosclerotic agents; they are much more stable than the natural prostacyclin derivatives.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1986</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNDw9AtxDXILDXL0i_Rx9XPVDQjyDw5xdI509vH0U3BxDfIMcwzxDHMN5mFgTUvMKU7lhdLcDPJuriHOHrqpBfnxqcUFicmpeakl8Y6hpkamhiYWZo7GhFUAAMUWI_w</recordid><startdate>19860724</startdate><enddate>19860724</enddate><creator>PAL HADHAZY</creator><creator>GYORGY DORMAN</creator><creator>SANDOR VIRAG</creator><creator>PETER KORMOCZI</creator><creator>ISTVAN TOMOSKOZY</creator><creator>JOZSEF IVANICS</creator><creator>KAROLY KANAY</creator><creator>ISTVAN STADLER</creator><creator>MIKLOS KISS</creator><creator>GEZA GALAMBOS</creator><creator>GABOR KOVACS</creator><scope>EVB</scope></search><sort><creationdate>19860724</creationdate><title>INTERFURANYLENE-PROSTACYCLIN DERIVATIVES</title><author>PAL HADHAZY ; GYORGY DORMAN ; SANDOR VIRAG ; PETER KORMOCZI ; ISTVAN TOMOSKOZY ; JOZSEF IVANICS ; KAROLY KANAY ; ISTVAN STADLER ; MIKLOS KISS ; GEZA GALAMBOS ; GABOR KOVACS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_AU5251486A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1986</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>PAL HADHAZY</creatorcontrib><creatorcontrib>GYORGY DORMAN</creatorcontrib><creatorcontrib>SANDOR VIRAG</creatorcontrib><creatorcontrib>PETER KORMOCZI</creatorcontrib><creatorcontrib>ISTVAN TOMOSKOZY</creatorcontrib><creatorcontrib>JOZSEF IVANICS</creatorcontrib><creatorcontrib>KAROLY KANAY</creatorcontrib><creatorcontrib>ISTVAN STADLER</creatorcontrib><creatorcontrib>MIKLOS KISS</creatorcontrib><creatorcontrib>GEZA GALAMBOS</creatorcontrib><creatorcontrib>GABOR KOVACS</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>PAL HADHAZY</au><au>GYORGY DORMAN</au><au>SANDOR VIRAG</au><au>PETER KORMOCZI</au><au>ISTVAN TOMOSKOZY</au><au>JOZSEF IVANICS</au><au>KAROLY KANAY</au><au>ISTVAN STADLER</au><au>MIKLOS KISS</au><au>GEZA GALAMBOS</au><au>GABOR KOVACS</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>INTERFURANYLENE-PROSTACYCLIN DERIVATIVES</title><date>1986-07-24</date><risdate>1986</risdate><abstract> The invention relates to novel interfuranylene-prosta-cyclin derivatives of the general formula (I)
wherein
R stands for hydrogen or a straight or branched chain C16 alkyl group, an inorganic cation or for the protonated form of a base containing an amino group;
R stands for hydrogen, a C1-4 alkanoyl or benzoyl group, a monosubstituted benzoyl, trialkylsilyl or an alkoxy-alkyl group;
R stands for a straight or branched chain C1-6 alkyl group, a phenyl group optionally substituted by halogen or by a C1-4 alkyl group, a heteroaryl group optionally substituted by halogen or by a C1-4 alkyl group or a cycloalkyl group;
A stands for an ethylene or for a cis- or trans-vinylene or -C IDENTICAL C- group;
B means a chemical bond, a -CHR -, -CHR -CH2- or a -CH2-O- group: and
R means hydrogen or a C1-4 alkyl group.
The compounds of the formula (I) can be used therapeutically as platelet aggregation inhibiting, anti-thrombotic, hypotensive and anti-antherosclerotic agents; they are much more stable than the natural prostacyclin derivatives.</abstract><edition>4</edition><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | INTERFURANYLENE-PROSTACYCLIN DERIVATIVES |
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