Dihydro-2h-naphthalene-1-one inhibitors of ras farnesyl transferase
The present invention provides dihydro-2H-napthalene-1-ones of formula (V), and pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, which are useful for treating and preventing uncontrolled or abnormal proliferation of tissues, such as cancer, atherosclerosis, restenosis, and ps...
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| creator | DANIELE MARIE LEONARD GORDON WILLIAM REWCASTLE JOSEPH THOMAS REPINE |
| description | The present invention provides dihydro-2H-napthalene-1-ones of formula (V), and pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, which are useful for treating and preventing uncontrolled or abnormal proliferation of tissues, such as cancer, atherosclerosis, restenosis, and psoriasis. Specifically, the present invention relates to compounds that inhibit the farnesyl transferase enzyme. |
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Specifically, the present invention relates to compounds that inhibit the farnesyl transferase enzyme.</description><edition>7</edition><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2001</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20011030&DB=EPODOC&CC=AU&NR=5164901A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20011030&DB=EPODOC&CC=AU&NR=5164901A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>DANIELE MARIE LEONARD</creatorcontrib><creatorcontrib>GORDON WILLIAM REWCASTLE</creatorcontrib><creatorcontrib>JOSEPH THOMAS REPINE</creatorcontrib><title>Dihydro-2h-naphthalene-1-one inhibitors of ras farnesyl transferase</title><description>The present invention provides dihydro-2H-napthalene-1-ones of formula (V), and pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, which are useful for treating and preventing uncontrolled or abnormal proliferation of tissues, such as cancer, atherosclerosis, restenosis, and psoriasis. Specifically, the present invention relates to compounds that inhibit the farnesyl transferase enzyme.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2001</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHB2ycyoTCnK1zXK0M1LLMgoyUjMSc1L1TXUzc9LVcjMy8hMyizJLypWyE9TKEosVkhLLMpLLa7MUSgpSswrTksFiqXyMLCmJeYUp_JCaW4GeTfXEGcP3dSC_PjU4oLEZKCJJfGOoaaGZiaWBoaOxoRVAACTZzF4</recordid><startdate>20011030</startdate><enddate>20011030</enddate><creator>DANIELE MARIE LEONARD</creator><creator>GORDON WILLIAM REWCASTLE</creator><creator>JOSEPH THOMAS REPINE</creator><scope>EVB</scope></search><sort><creationdate>20011030</creationdate><title>Dihydro-2h-naphthalene-1-one inhibitors of ras farnesyl transferase</title><author>DANIELE MARIE LEONARD ; GORDON WILLIAM REWCASTLE ; JOSEPH THOMAS REPINE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_AU5164901A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2001</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>DANIELE MARIE LEONARD</creatorcontrib><creatorcontrib>GORDON WILLIAM REWCASTLE</creatorcontrib><creatorcontrib>JOSEPH THOMAS REPINE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>DANIELE MARIE LEONARD</au><au>GORDON WILLIAM REWCASTLE</au><au>JOSEPH THOMAS REPINE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Dihydro-2h-naphthalene-1-one inhibitors of ras farnesyl transferase</title><date>2001-10-30</date><risdate>2001</risdate><abstract>The present invention provides dihydro-2H-napthalene-1-ones of formula (V), and pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, which are useful for treating and preventing uncontrolled or abnormal proliferation of tissues, such as cancer, atherosclerosis, restenosis, and psoriasis. 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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Dihydro-2h-naphthalene-1-one inhibitors of ras farnesyl transferase |
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