Spiroheterocyclic nitriles useful as reversible inhibitors of cysteine proteases
Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (I), (II), (Ia) and (Ib) further defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are processes for making such novel compounds.
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| creator | DAVID S THOMSON WIEMEN LIU SANXING SUN EUGENE R. HICKEY YANCEY D. WARD ERICK R. R. YOUNG DENISE M. SPERO YOUNES BEKKALI USHA R. PATEL |
| description | Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (I), (II), (Ia) and (Ib) further defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are processes for making such novel compounds. |
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SPERO</creatorcontrib><creatorcontrib>YOUNES BEKKALI</creatorcontrib><creatorcontrib>USHA R. PATEL</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>DAVID S THOMSON</au><au>WIEMEN LIU</au><au>SANXING SUN</au><au>EUGENE R. HICKEY</au><au>YANCEY D. WARD</au><au>ERICK R. R. YOUNG</au><au>DENISE M. SPERO</au><au>YOUNES BEKKALI</au><au>USHA R. PATEL</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Spiroheterocyclic nitriles useful as reversible inhibitors of cysteine proteases</title><date>2002-03-22</date><risdate>2002</risdate><abstract>Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (I), (II), (Ia) and (Ib) further defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are processes for making such novel compounds.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Spiroheterocyclic nitriles useful as reversible inhibitors of cysteine proteases |
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