CEPHALOSPORIN COMPOUNDS

1361183 Cephalosporin compounds GLAXO LABORATORIES Ltd 15 July 1971 [6 Aug 1970] 38021/70 Heading C2A 3-Ethyl and 3-substituted ethyl cephalosporin compounds of general formula (I): wherein R1 is hydrogen or a carboxylic acyl group, R2 is hydrogen or a carboxyl blocking group, R3 and R4 are identica...

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1. Verfasser:	NIALL GALBRAITH WEIR
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Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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creator	NIALL GALBRAITH WEIR
description	1361183 Cephalosporin compounds GLAXO LABORATORIES Ltd 15 July 1971 [6 Aug 1970] 38021/70 Heading C2A 3-Ethyl and 3-substituted ethyl cephalosporin compounds of general formula (I): wherein R1 is hydrogen or a carboxylic acyl group, R2 is hydrogen or a carboxyl blocking group, R3 and R4 are identical or different and each is a hydrogen atom or an organic group, Z is > S or > S#O, and the dotted line signifies a double bond in the 2,3- or 3,4-position, the said compounds being novel when R3 and R4 are each hydrogen or one of R3 and R4 is hydrogen and the other is cyano, are prepared by reducing a cephalosporin compound of Formula (II) to hydrogenate the methylene group at the 3-position. The reduction may be effected by hydrogenation in the presence of a noble metal catalyst, by treatment with a diimine, or with zinc and an acid (e.g. acetic or formic acid), or with a metallohydride. The compounds (I) have antibiotic activity and may be formulated into pharmaceutical compositions with a suitable diluent or carrier.
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The reduction may be effected by hydrogenation in the presence of a noble metal catalyst, by treatment with a diimine, or with zinc and an acid (e.g. acetic or formic acid), or with a metallohydride. The compounds (I) have antibiotic activity and may be formulated into pharmaceutical compositions with a suitable diluent or carrier.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>1973</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19730208&DB=EPODOC&CC=AU&NR=3204071A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25568,76551</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19730208&DB=EPODOC&CC=AU&NR=3204071A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>NIALL GALBRAITH WEIR</creatorcontrib><title>CEPHALOSPORIN COMPOUNDS</title><description>1361183 Cephalosporin compounds GLAXO LABORATORIES Ltd 15 July 1971 [6 Aug 1970] 38021/70 Heading C2A 3-Ethyl and 3-substituted ethyl cephalosporin compounds of general formula (I): wherein R1 is hydrogen or a carboxylic acyl group, R2 is hydrogen or a carboxyl blocking group, R3 and R4 are identical or different and each is a hydrogen atom or an organic group, Z is > S or > S#O, and the dotted line signifies a double bond in the 2,3- or 3,4-position, the said compounds being novel when R3 and R4 are each hydrogen or one of R3 and R4 is hydrogen and the other is cyano, are prepared by reducing a cephalosporin compound of Formula (II) to hydrogenate the methylene group at the 3-position. The reduction may be effected by hydrogenation in the presence of a noble metal catalyst, by treatment with a diimine, or with zinc and an acid (e.g. acetic or formic acid), or with a metallohydride. 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The reduction may be effected by hydrogenation in the presence of a noble metal catalyst, by treatment with a diimine, or with zinc and an acid (e.g. acetic or formic acid), or with a metallohydride. The compounds (I) have antibiotic activity and may be formulated into pharmaceutical compositions with a suitable diluent or carrier.</abstract><oa>free_for_read</oa></addata></record>
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subjects	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
title	CEPHALOSPORIN COMPOUNDS
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