Compounds which inhibit leukocyte adhesion mediated by vla-4
Disclosed are compounds such as Ia and Ib which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Al...
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| creator | DIMITRIOS SARANTAKIS MICHAEL A PLEISS CHRISTINE M. TARBY CHRISTOPHER JOSEPH SOARES SUSAN ASHWELL GREGORY S. WELMAKER KIEV SUI LY ANDREI W. KONRADI CHRISTOPHER SEMKO ANTHONY KREFT ROBERT WARREN SULLIVAN EUGENE D. THORSETT |
| description | Disclosed are compounds such as Ia and Ib which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiples sclerosis. |
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THORSETT</creator><creatorcontrib>DIMITRIOS SARANTAKIS ; MICHAEL A PLEISS ; CHRISTINE M. TARBY ; CHRISTOPHER JOSEPH SOARES ; SUSAN ASHWELL ; GREGORY S. WELMAKER ; KIEV SUI LY ; ANDREI W. KONRADI ; CHRISTOPHER SEMKO ; ANTHONY KREFT ; ROBERT WARREN SULLIVAN ; EUGENE D. THORSETT</creatorcontrib><description>Disclosed are compounds such as Ia and Ib which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. 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The compounds can also be administered for the treatment of inflammatory brain diseases such as multiples sclerosis.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2000</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLBxzs8tyC_NSylWKM_ITM5QyMzLyEzKLFHISS3Nzk-uLElVSEzJSC3OzM9TyE1NyUwsSU1RSKpUKMtJ1DXhYWBNS8wpTuWF0twM8m6uIc4euqkF-fGpxQWJyal5qSXxjqFGZkbGlgYGjsaEVQAAKgsuww</recordid><startdate>20000807</startdate><enddate>20000807</enddate><creator>DIMITRIOS SARANTAKIS</creator><creator>MICHAEL A PLEISS</creator><creator>CHRISTINE M. 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WELMAKER</creatorcontrib><creatorcontrib>KIEV SUI LY</creatorcontrib><creatorcontrib>ANDREI W. KONRADI</creatorcontrib><creatorcontrib>CHRISTOPHER SEMKO</creatorcontrib><creatorcontrib>ANTHONY KREFT</creatorcontrib><creatorcontrib>ROBERT WARREN SULLIVAN</creatorcontrib><creatorcontrib>EUGENE D. THORSETT</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>DIMITRIOS SARANTAKIS</au><au>MICHAEL A PLEISS</au><au>CHRISTINE M. TARBY</au><au>CHRISTOPHER JOSEPH SOARES</au><au>SUSAN ASHWELL</au><au>GREGORY S. WELMAKER</au><au>KIEV SUI LY</au><au>ANDREI W. KONRADI</au><au>CHRISTOPHER SEMKO</au><au>ANTHONY KREFT</au><au>ROBERT WARREN SULLIVAN</au><au>EUGENE D. THORSETT</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Compounds which inhibit leukocyte adhesion mediated by vla-4</title><date>2000-08-07</date><risdate>2000</risdate><abstract>Disclosed are compounds such as Ia and Ib which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiples sclerosis.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Compounds which inhibit leukocyte adhesion mediated by vla-4 |
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