CEPHALOSPORINS
New cephalosporins of formula (I) and their esters and salts: In the formula R is H, 1-9C alkyl opt. substd. by F, Cl, Br, COOH, 1-5C alkoxy, 1-4C alkanoyloxy or 2-5C alkoxycarbonyl, or 1-10C alkoxy opt. substd. by F, Cl, Br, 1-5C alkoxy, 1-4C alkanoyloxy or 2-5C alkoxycarbonyl; R1 is H, acetoxy or...
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| creator | RUDOLF GOITSCHLICH JURGEN SEUBERT DR ROLF BERGMANN ROLF GERICKE HELMUT WAHLIG ELVIRA DINGELDEIN HORST JURASZYK WIGHARD STREHLOW |
| description | New cephalosporins of formula (I) and their esters and salts: In the formula R is H, 1-9C alkyl opt. substd. by F, Cl, Br, COOH, 1-5C alkoxy, 1-4C alkanoyloxy or 2-5C alkoxycarbonyl, or 1-10C alkoxy opt. substd. by F, Cl, Br, 1-5C alkoxy, 1-4C alkanoyloxy or 2-5C alkoxycarbonyl; R1 is H, acetoxy or S-Het; Het is 1,2,3-triazol-5-yl, 1-methyltetrazol-5-, 1,3,4-thiadiazol-2-yl or 2-methyl-1,3,4-thiazdiazol-5-yl. Cpds. (I) are broad-spectrum antibacterials, e.g. orally effective against Staph. aureus infections at a daily dose of 10-60 mg/kg. A typical cpd. is 7- D-2-amino-2-(3-propionyloxyphenyl) acetamido -3-methyl-3-cephem-4-carboxylic acid, which may be prepd. from 7- D-2-t-butyloxycarbonylamino-2-(3-hydroxyphenyl)acetamido -3-me- thyl-3-cephem-4-carboxylic acid. |
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Cpds. (I) are broad-spectrum antibacterials, e.g. orally effective against Staph. aureus infections at a daily dose of 10-60 mg/kg. A typical cpd. is 7- D-2-amino-2-(3-propionyloxyphenyl) acetamido -3-methyl-3-cephem-4-carboxylic acid, which may be prepd. from 7- D-2-t-butyloxycarbonylamino-2-(3-hydroxyphenyl)acetamido -3-me- thyl-3-cephem-4-carboxylic acid.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1978</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19780921&DB=EPODOC&CC=AU&NR=2334377A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76294</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19780921&DB=EPODOC&CC=AU&NR=2334377A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>RUDOLF GOITSCHLICH</creatorcontrib><creatorcontrib>JURGEN SEUBERT</creatorcontrib><creatorcontrib>DR ROLF BERGMANN</creatorcontrib><creatorcontrib>ROLF GERICKE</creatorcontrib><creatorcontrib>HELMUT WAHLIG</creatorcontrib><creatorcontrib>ELVIRA DINGELDEIN</creatorcontrib><creatorcontrib>HORST JURASZYK</creatorcontrib><creatorcontrib>WIGHARD STREHLOW</creatorcontrib><title>CEPHALOSPORINS</title><description>New cephalosporins of formula (I) and their esters and salts: In the formula R is H, 1-9C alkyl opt. substd. by F, Cl, Br, COOH, 1-5C alkoxy, 1-4C alkanoyloxy or 2-5C alkoxycarbonyl, or 1-10C alkoxy opt. substd. by F, Cl, Br, 1-5C alkoxy, 1-4C alkanoyloxy or 2-5C alkoxycarbonyl; R1 is H, acetoxy or S-Het; Het is 1,2,3-triazol-5-yl, 1-methyltetrazol-5-, 1,3,4-thiadiazol-2-yl or 2-methyl-1,3,4-thiazdiazol-5-yl. Cpds. (I) are broad-spectrum antibacterials, e.g. orally effective against Staph. aureus infections at a daily dose of 10-60 mg/kg. A typical cpd. is 7- D-2-amino-2-(3-propionyloxyphenyl) acetamido -3-methyl-3-cephem-4-carboxylic acid, which may be prepd. from 7- D-2-t-butyloxycarbonylamino-2-(3-hydroxyphenyl)acetamido -3-me- thyl-3-cephem-4-carboxylic acid.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1978</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZOBzdg3wcPTxDw7wD_L0C-ZhYE1LzClO5YXS3Azybq4hzh66qQX58anFBYnJqXmpJfGOoUbGxibG5uaOxoRVAABtxhxf</recordid><startdate>19780921</startdate><enddate>19780921</enddate><creator>RUDOLF GOITSCHLICH</creator><creator>JURGEN SEUBERT</creator><creator>DR ROLF BERGMANN</creator><creator>ROLF GERICKE</creator><creator>HELMUT WAHLIG</creator><creator>ELVIRA DINGELDEIN</creator><creator>HORST JURASZYK</creator><creator>WIGHARD STREHLOW</creator><scope>EVB</scope></search><sort><creationdate>19780921</creationdate><title>CEPHALOSPORINS</title><author>RUDOLF GOITSCHLICH ; JURGEN SEUBERT ; DR ROLF BERGMANN ; ROLF GERICKE ; HELMUT WAHLIG ; ELVIRA DINGELDEIN ; HORST JURASZYK ; WIGHARD STREHLOW</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_AU2334377A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1978</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>RUDOLF GOITSCHLICH</creatorcontrib><creatorcontrib>JURGEN SEUBERT</creatorcontrib><creatorcontrib>DR ROLF BERGMANN</creatorcontrib><creatorcontrib>ROLF GERICKE</creatorcontrib><creatorcontrib>HELMUT WAHLIG</creatorcontrib><creatorcontrib>ELVIRA DINGELDEIN</creatorcontrib><creatorcontrib>HORST JURASZYK</creatorcontrib><creatorcontrib>WIGHARD STREHLOW</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>RUDOLF GOITSCHLICH</au><au>JURGEN SEUBERT</au><au>DR ROLF BERGMANN</au><au>ROLF GERICKE</au><au>HELMUT WAHLIG</au><au>ELVIRA DINGELDEIN</au><au>HORST JURASZYK</au><au>WIGHARD STREHLOW</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>CEPHALOSPORINS</title><date>1978-09-21</date><risdate>1978</risdate><abstract>New cephalosporins of formula (I) and their esters and salts: In the formula R is H, 1-9C alkyl opt. substd. by F, Cl, Br, COOH, 1-5C alkoxy, 1-4C alkanoyloxy or 2-5C alkoxycarbonyl, or 1-10C alkoxy opt. substd. by F, Cl, Br, 1-5C alkoxy, 1-4C alkanoyloxy or 2-5C alkoxycarbonyl; R1 is H, acetoxy or S-Het; Het is 1,2,3-triazol-5-yl, 1-methyltetrazol-5-, 1,3,4-thiadiazol-2-yl or 2-methyl-1,3,4-thiazdiazol-5-yl. Cpds. (I) are broad-spectrum antibacterials, e.g. orally effective against Staph. aureus infections at a daily dose of 10-60 mg/kg. A typical cpd. is 7- D-2-amino-2-(3-propionyloxyphenyl) acetamido -3-methyl-3-cephem-4-carboxylic acid, which may be prepd. from 7- D-2-t-butyloxycarbonylamino-2-(3-hydroxyphenyl)acetamido -3-me- thyl-3-cephem-4-carboxylic acid.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | CEPHALOSPORINS |
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