Segmented chelating polymers as imaging and therapeutic agents
A composition suitable for use in diagnostic imaging or as a cell killing agent comprising a chelating residue linked via an amide linkage to a poly(alkylene oxide) moiety, said composition having a molecular weight of at least 4,500; wherein: Z is a chelating residue; Q is a divalent poly(alkylene...
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| creator | JULIA SHIEH TAN DENNIS KIYOSHI FUJII ROBERT ALLAN SNOW JOHN LUKE TONER DENNIS EARL BUTTERFIELD DAVID LEE LADD |
| description | A composition suitable for use in diagnostic imaging or as a cell killing agent comprising a chelating residue linked via an amide linkage to a poly(alkylene oxide) moiety, said composition having a molecular weight of at least 4,500; wherein: Z is a chelating residue; Q is a divalent poly(alkylene oxidylene) moiety having a carbon terminus at R and at L; L represents an amide linkage; E(b) is one or more counterions each having a charge of b; b is an integer from 1, 2 and 3; n is an integer selected from the group 1, 2, 3 and 4; w is zero or an integer from 1 to 5; M(+a) is a cation, having a charge of +a; a is an integer from 1 to 4; r is 0 or an integer from 1 to 3, provided that when r is 2-3, each M(+a) can be the same or different cation; d is the total charge on the chelating residue and is an integer from 0 to 10; d+ SIGMA (bxw)+ SIGMA (axr)=O; and R is a capping moiety chosen from the group consisting of hydrogen, hydroxyl, C1-C4 alkyl, aryl containing 6 to 24 carbon atoms, C2-C5 alkanoyloxyl and C1-C4 alkoxy, or R is an immunoreactive group or cytotoxic drug linked to Q by a chemical bond or a linking group. |
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HUMAN NECESSITIES ; HYGIENE ; MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC MACROMOLECULAR COMPOUNDS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; THEIR PREPARATION OR CHEMICAL WORKING-UP</subject><creationdate>1995</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19951023&DB=EPODOC&CC=AU&NR=2080595A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19951023&DB=EPODOC&CC=AU&NR=2080595A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>JULIA SHIEH TAN</creatorcontrib><creatorcontrib>DENNIS KIYOSHI FUJII</creatorcontrib><creatorcontrib>ROBERT ALLAN SNOW</creatorcontrib><creatorcontrib>JOHN LUKE TONER</creatorcontrib><creatorcontrib>DENNIS EARL BUTTERFIELD</creatorcontrib><creatorcontrib>DAVID LEE LADD</creatorcontrib><title>Segmented chelating polymers as imaging and therapeutic agents</title><description>A composition suitable for use in diagnostic imaging or as a cell killing agent comprising a chelating residue linked via an amide linkage to a poly(alkylene oxide) moiety, said composition having a molecular weight of at least 4,500; 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wherein: Z is a chelating residue; Q is a divalent poly(alkylene oxidylene) moiety having a carbon terminus at R and at L; L represents an amide linkage; E(b) is one or more counterions each having a charge of b; b is an integer from 1, 2 and 3; n is an integer selected from the group 1, 2, 3 and 4; w is zero or an integer from 1 to 5; M(+a) is a cation, having a charge of +a; a is an integer from 1 to 4; r is 0 or an integer from 1 to 3, provided that when r is 2-3, each M(+a) can be the same or different cation; d is the total charge on the chelating residue and is an integer from 0 to 10; d+ SIGMA (bxw)+ SIGMA (axr)=O; and R is a capping moiety chosen from the group consisting of hydrogen, hydroxyl, C1-C4 alkyl, aryl containing 6 to 24 carbon atoms, C2-C5 alkanoyloxyl and C1-C4 alkoxy, or R is an immunoreactive group or cytotoxic drug linked to Q by a chemical bond or a linking group.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY COMPOSITIONS BASED THEREON HUMAN NECESSITIES HYGIENE MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC MACROMOLECULAR COMPOUNDS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES THEIR PREPARATION OR CHEMICAL WORKING-UP |
| title | Segmented chelating polymers as imaging and therapeutic agents |
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