NICLOSAMIDE FORMULATIONS

NICLOSAMIDE FORMULATIONS

1527638 Oil-based suspensions of niclosamide BAYER AG 14 Dec 1976 [20 Dec 1975] 52104/76 Heading A5B Orally administrable pharmaceutical or veterinary anthelmintic compositions consist of an oil-based suspension of niclosamide (2-hydroxy-5-2'-dichloro-4'-nitrobenzanilide) or a salt thereof...

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Hauptverfasser: HERBERT THOMAS, KARL ERNST FETTING, HERBERT VOEGE, KURT BAUER, RUDOLF GONNERT
Format: Patent
Sprache:eng
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator HERBERT THOMAS
KARL ERNST FETTING
HERBERT VOEGE
KURT BAUER
RUDOLF GONNERT
description 1527638 Oil-based suspensions of niclosamide BAYER AG 14 Dec 1976 [20 Dec 1975] 52104/76 Heading A5B Orally administrable pharmaceutical or veterinary anthelmintic compositions consist of an oil-based suspension of niclosamide (2-hydroxy-5-2'-dichloro-4'-nitrobenzanilide) or a salt thereof, in which at least 50% of the particles of niclosamide or its salt are smaller than 2Á. The active compound may be anhydrous or contain water of crystallisation, and may be in the form of its piperazine (also anthelmintically active) salt. The composition may contain a surface-active agent (e.g. lecithin or a polyoxyethylated sorbitan monolaurate, or other anionic, cationic, ampholytic or non-ionic surfactants. Suitable oils are liquid paraffin and/or sesame oil. The compositions are prepared by grinding the niclosamide in the oil until the required particle size is reached, and optionally adding further oil and/or a surface active agent. The compositions are said to have improved storage stability and anthelmintic activity.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title NICLOSAMIDE FORMULATIONS
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