Methods for radiolabelling GRPR antagonists and their kits

Methods for radiolabelling GRPR antagonists and their kits

The present invention relates to methods for radiolabelling GRPR antagonists such as NeoB, and their kits. In particular, the invention to a method for labeling a gastrin-releasing peptide receptor (GRPR) antagonist with a radioactive isotope, preferably 6 8 Ga, 67Ga or 64Cu, said 5 method comprisin...

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Hauptverfasser: CASTALDI, Elena, ORLANDI, Francesca, TEDESCO, Mattia, FUGAZZA, Lorenza, MARIANI, Maurizio F
Format: Patent
Sprache:eng
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator CASTALDI, Elena
ORLANDI, Francesca
TEDESCO, Mattia
FUGAZZA, Lorenza
MARIANI, Maurizio F
description The present invention relates to methods for radiolabelling GRPR antagonists such as NeoB, and their kits. In particular, the invention to a method for labeling a gastrin-releasing peptide receptor (GRPR) antagonist with a radioactive isotope, preferably 6 8 Ga, 67Ga or 64Cu, said 5 method comprising the steps of: i. providing a first vial comprising said GRPR antagonist in dried form, ii. adding a solution of said radioactive isotope into said first vial, thereby obtaining a solution of said GRPR antagonist with said radioactive isotope, iii. mixing the solution obtained in ii. with at least a buffering agent and 10 incubating it for a sufficient period of time for obtaining said GRPR antagonist labeled with said radioactive isotope, and, iv. optionally, adjusting the pH of the solution.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title Methods for radiolabelling GRPR antagonists and their kits
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