T CELL RECEPTOR MULTIMERS AND USES THEREOF
T cell receptor (TCR) multimers are provided in which a binding moiety from a T cell receptor variable region is attached to a multimerization moiety from IgM or IgA to thereby create a multivalent TCR multimer composition. The TCR multimers can be used, for example, to determine the binding specifi...
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| creator | SWAIN, Joanna HAMEL, Andrew MALIA, Thomas |
| description | T cell receptor (TCR) multimers are provided in which a binding moiety from a T cell receptor variable region is attached to a multimerization moiety from IgM or IgA to thereby create a multivalent TCR multimer composition. The TCR multimers can be used, for example, to determine the binding specificity of the TCR-derived binding moiety, such as for particular MHC-peptide complexes. The multimers can also be used, for example, to modulate an immune response in a subject by administering the multimer to the subject. Methods of making the TCR multimers are also provided. |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | T CELL RECEPTOR MULTIMERS AND USES THEREOF |
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