T CELL RECEPTOR MULTIMERS AND USES THEREOF

T CELL RECEPTOR MULTIMERS AND USES THEREOF

T cell receptor (TCR) multimers are provided in which a binding moiety from a T cell receptor variable region is attached to a multimerization moiety from IgM or IgA to thereby create a multivalent TCR multimer composition. The TCR multimers can be used, for example, to determine the binding specifi...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SWAIN, Joanna, HAMEL, Andrew, MALIA, Thomas
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:T cell receptor (TCR) multimers are provided in which a binding moiety from a T cell receptor variable region is attached to a multimerization moiety from IgM or IgA to thereby create a multivalent TCR multimer composition. The TCR multimers can be used, for example, to determine the binding specificity of the TCR-derived binding moiety, such as for particular MHC-peptide complexes. The multimers can also be used, for example, to modulate an immune response in a subject by administering the multimer to the subject. Methods of making the TCR multimers are also provided.