T CELL AND NK CELL ENGAGERS
The present disclosure pertains to T cell and/or NK cell engaging agents, and uses thereof. In some embodiments, the present disclosure provides bispecific antibody molecules or antigen-binding fragments thereof comprising (i) a first antigen-binding domain that selectively binds to transmembrane an...
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| creator | RAUSCH, Matthew ETEMAD-GILBERTSON, Bijan |
| description | The present disclosure pertains to T cell and/or NK cell engaging agents, and uses thereof. In some embodiments, the present disclosure provides bispecific antibody molecules or antigen-binding fragments thereof comprising (i) a first antigen-binding domain that selectively binds to transmembrane and immunoglobulin domain containing 2 (TMIGD2); and (ii) a second antigen-binding domain that selectively binds to at least one tumor-associated antigen (TAA). Such agents disclosed herein (e.g., bispecific antibody molecules or antigen-binding fragments thereof) can be used in methods of treating a subject having a disease, disorder, or condition and/or modulating an immune response in a subject. |
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In some embodiments, the present disclosure provides bispecific antibody molecules or antigen-binding fragments thereof comprising (i) a first antigen-binding domain that selectively binds to transmembrane and immunoglobulin domain containing 2 (TMIGD2); and (ii) a second antigen-binding domain that selectively binds to at least one tumor-associated antigen (TAA). Such agents disclosed herein (e.g., bispecific antibody molecules or antigen-binding fragments thereof) can be used in methods of treating a subject having a disease, disorder, or condition and/or modulating an immune response in a subject.</description><language>eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PHYSICS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; TESTING ; VINEGAR ; WINE</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240801&DB=EPODOC&CC=AU&NR=2023217006A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25562,76317</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240801&DB=EPODOC&CC=AU&NR=2023217006A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>RAUSCH, Matthew</creatorcontrib><creatorcontrib>ETEMAD-GILBERTSON, Bijan</creatorcontrib><title>T CELL AND NK CELL ENGAGERS</title><description>The present disclosure pertains to T cell and/or NK cell engaging agents, and uses thereof. In some embodiments, the present disclosure provides bispecific antibody molecules or antigen-binding fragments thereof comprising (i) a first antigen-binding domain that selectively binds to transmembrane and immunoglobulin domain containing 2 (TMIGD2); and (ii) a second antigen-binding domain that selectively binds to at least one tumor-associated antigen (TAA). 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In some embodiments, the present disclosure provides bispecific antibody molecules or antigen-binding fragments thereof comprising (i) a first antigen-binding domain that selectively binds to transmembrane and immunoglobulin domain containing 2 (TMIGD2); and (ii) a second antigen-binding domain that selectively binds to at least one tumor-associated antigen (TAA). Such agents disclosed herein (e.g., bispecific antibody molecules or antigen-binding fragments thereof) can be used in methods of treating a subject having a disease, disorder, or condition and/or modulating an immune response in a subject.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE |
| title | T CELL AND NK CELL ENGAGERS |
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