AN EPIGENTIC CLOCK FOR THE GALLIFORMES FAMILY
The present invention relates to an in vitro method for predicting the biological age of a subject, the method comprising the steps of: (a) bisulfite treatment of genomic DNA extracted from a biological sample obtained from the subject; (b) amplifying the bisulfite treated genomic DNA from step (a)...
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| creator | LYKO-TÖNGES, Sina PFEFFERLE, Walter NAGARAJAN, Sanjanaa RADDATZ, Günter BÖHL, Florian BOURLAND, Jennifer WHELAN, Rose ROY, Suki LYKO, Frank |
| description | The present invention relates to an in vitro method for predicting the biological age of a subject, the method comprising the steps of: (a) bisulfite treatment of genomic DNA extracted from a biological sample obtained from the subject; (b) amplifying the bisulfite treated genomic DNA from step (a) with specific primers that target at least two Low Methylated Region (LMR) in the genomic DNA from (a) to obtain at least one PCR product; (c) measuring the methylation level of CpG sites in the PCR product of step (b); (d) determining the biological age of the subject with a statistical prediction algorithm, wherein the statistical prediction algorithm is applied to the measured methylation level to determine the epigenetic age of the subject wherein the subject is from the |
| format | Patent |
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ROY, Suki ; LYKO, Frank</creatorcontrib><description>The present invention relates to an in vitro method for predicting the biological age of a subject, the method comprising the steps of: (a) bisulfite treatment of genomic DNA extracted from a biological sample obtained from the subject; (b) amplifying the bisulfite treated genomic DNA from step (a) with specific primers that target at least two Low Methylated Region (LMR) in the genomic DNA from (a) to obtain at least one PCR product; (c) measuring the methylation level of CpG sites in the PCR product of step (b); (d) determining the biological age of the subject with a statistical prediction algorithm, wherein the statistical prediction algorithm is applied to the measured methylation level to determine the epigenetic age of the subject wherein the subject is from the</description><language>eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; 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(b) amplifying the bisulfite treated genomic DNA from step (a) with specific primers that target at least two Low Methylated Region (LMR) in the genomic DNA from (a) to obtain at least one PCR product; (c) measuring the methylation level of CpG sites in the PCR product of step (b); (d) determining the biological age of the subject with a statistical prediction algorithm, wherein the statistical prediction algorithm is applied to the measured methylation level to determine the epigenetic age of the subject wherein the subject is from the</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>ENZYMOLOGY</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNB19FNwDfB0d_UL8XRWcPbxd_ZWcPMPUgjxcFVwd_Tx8QRyfF2DFdwcfT19InkYWNMSc4pTeaE0N4Oym2uIs4duakF-fGpxQWJyal5qSbxjqJGBkbGRoYm5kYmjoTFxqgAn5CXs</recordid><startdate>20240919</startdate><enddate>20240919</enddate><creator>LYKO-TÖNGES, Sina</creator><creator>PFEFFERLE, Walter</creator><creator>NAGARAJAN, Sanjanaa</creator><creator>RADDATZ, Günter</creator><creator>BÖHL, Florian</creator><creator>BOURLAND, Jennifer</creator><creator>WHELAN, Rose</creator><creator>ROY, Suki</creator><creator>LYKO, Frank</creator><scope>EVB</scope></search><sort><creationdate>20240919</creationdate><title>AN EPIGENTIC CLOCK FOR THE GALLIFORMES FAMILY</title><author>LYKO-TÖNGES, Sina ; 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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS VINEGAR WINE |
| title | AN EPIGENTIC CLOCK FOR THE GALLIFORMES FAMILY |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T08%3A15%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=LYKO-T%C3%96NGES,%20Sina&rft.date=2024-09-19&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EAU2023214724A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |