Combination treatment for solid tumors using docetaxel and a cyp3a inhibitor

Combination treatment for solid tumors using docetaxel and a cyp3a inhibitor

Abstract Treatments of cancers involve a wide range of treatment. The current invention relates to chemotherapy of tumors using taxanes, in particular docetaxel. More in particular it relates to achieving efficacious doses of orally administered doses docetaxel whilst maintaining acceptable safety....

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Hauptverfasser: BEIJNEN, Jacob Hendrik, SCHELLENS, Johannes Henricus Matthias
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Sprache:eng
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator BEIJNEN, Jacob Hendrik
SCHELLENS, Johannes Henricus Matthias
description Abstract Treatments of cancers involve a wide range of treatment. The current invention relates to chemotherapy of tumors using taxanes, in particular docetaxel. More in particular it relates to achieving efficacious doses of orally administered doses docetaxel whilst maintaining acceptable safety. By providing novel means and methods, combining oral docetaxel with a CYP3A inhibitor, the inventors have established improved treatments of cancer, said methods and means providing for an improved safety profile of docetaxel as compared with the standard of treatment for docetaxel, while at the same time allowing to obtain efficacious levels of docetaxel to eradicate cancer cells.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Combination treatment for solid tumors using docetaxel and a cyp3a inhibitor
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