ENGINEERED SIRPα VARIANTS AND METHODS OF USE THEREOF

ENGINEERED SIRPα VARIANTS AND METHODS OF USE THEREOF

Signal regulatory protein a (SIRPa) is a regulatory membrane glycoprotein from SIRP family. It is mainly expressed by myeloid cells and also by stem cells or neurons. SIRPa acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47. This disclosure relates to engin...

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Bibliographische Detailangaben
Hauptverfasser: WANG, Jiin-Tarng, KUO, Pan-Hsien, TSENG, Chi-Ling, JUO, Zong Sean, TENG, Han-Fang
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Signal regulatory protein a (SIRPa) is a regulatory membrane glycoprotein from SIRP family. It is mainly expressed by myeloid cells and also by stem cells or neurons. SIRPa acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47. This disclosure relates to engineered SIRPa variants, and methods of use thereof.