ANTI-ABCB1 ANTIBODIES

Provided are anti-ABCB1 antibodies that may be used as multi-specific, including bispecific, antibodies targeting both ABCB1 and a tumor-associated antigen (TAA), as well as pharmaceutical compositions, nucleic acids, recombinant expression vectors, cells, and kits that include or encode such antibo...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	PONATH, Paul David, O'CONNOR, Alissa Loren, ZHAI, Qianting, ARATHOON, William Robert, ABUHAY, Mastewal, BRIANTE, Raffaella, ZHANG, Pingping, TAN, Cindy
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

container_end_page
container_issue
container_start_page
container_title
container_volume
creator	PONATH, Paul David O'CONNOR, Alissa Loren ZHAI, Qianting ARATHOON, William Robert ABUHAY, Mastewal BRIANTE, Raffaella ZHANG, Pingping TAN, Cindy
description	Provided are anti-ABCB1 antibodies that may be used as multi-specific, including bispecific, antibodies targeting both ABCB1 and a tumor-associated antigen (TAA), as well as pharmaceutical compositions, nucleic acids, recombinant expression vectors, cells, and kits that include or encode such antibodies and multi-specific antibodies. Further included are uses and methods of treating conditions where inhibition of ABCB1-mediated efflux transport is desirable, such as, cancer or multi-drug resistance mediated by the ABCB1 transporter, e.g., multi-drug resistant cancer. In particular, the disclosure provides humanized multi-specific, e.g. bispecific, IgG (IgG1) antibodies that bind ABCB1 and a TAA. Multi-specific IgG1 antibody molecules are provided with Fc substitutions in at least one of a first and a second heavy chain constant region.
format	Patent
fullrecord	<record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_AU2022413942A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>AU2022413942A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_AU2022413942A13</originalsourceid><addsrcrecordid>eNrjZBB19Avx1HV0cnYyVAAxnfxdPF2DeRhY0xJzilN5oTQ3g7Kba4izh25qQX58anFBYnJqXmpJvGOokYGRkYmhsaWJkaOhMXGqAO3YH1o</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>ANTI-ABCB1 ANTIBODIES</title><source>esp@cenet</source><creator>PONATH, Paul David ; O'CONNOR, Alissa Loren ; ZHAI, Qianting ; ARATHOON, William Robert ; ABUHAY, Mastewal ; BRIANTE, Raffaella ; ZHANG, Pingping ; TAN, Cindy</creator><creatorcontrib>PONATH, Paul David ; O'CONNOR, Alissa Loren ; ZHAI, Qianting ; ARATHOON, William Robert ; ABUHAY, Mastewal ; BRIANTE, Raffaella ; ZHANG, Pingping ; TAN, Cindy</creatorcontrib><description>Provided are anti-ABCB1 antibodies that may be used as multi-specific, including bispecific, antibodies targeting both ABCB1 and a tumor-associated antigen (TAA), as well as pharmaceutical compositions, nucleic acids, recombinant expression vectors, cells, and kits that include or encode such antibodies and multi-specific antibodies. Further included are uses and methods of treating conditions where inhibition of ABCB1-mediated efflux transport is desirable, such as, cancer or multi-drug resistance mediated by the ABCB1 transporter, e.g., multi-drug resistant cancer. In particular, the disclosure provides humanized multi-specific, e.g. bispecific, IgG (IgG1) antibodies that bind ABCB1 and a TAA. Multi-specific IgG1 antibody molecules are provided with Fc substitutions in at least one of a first and a second heavy chain constant region.</description><language>eng</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240530&DB=EPODOC&CC=AU&NR=2022413942A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240530&DB=EPODOC&CC=AU&NR=2022413942A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>PONATH, Paul David</creatorcontrib><creatorcontrib>O'CONNOR, Alissa Loren</creatorcontrib><creatorcontrib>ZHAI, Qianting</creatorcontrib><creatorcontrib>ARATHOON, William Robert</creatorcontrib><creatorcontrib>ABUHAY, Mastewal</creatorcontrib><creatorcontrib>BRIANTE, Raffaella</creatorcontrib><creatorcontrib>ZHANG, Pingping</creatorcontrib><creatorcontrib>TAN, Cindy</creatorcontrib><title>ANTI-ABCB1 ANTIBODIES</title><description>Provided are anti-ABCB1 antibodies that may be used as multi-specific, including bispecific, antibodies targeting both ABCB1 and a tumor-associated antigen (TAA), as well as pharmaceutical compositions, nucleic acids, recombinant expression vectors, cells, and kits that include or encode such antibodies and multi-specific antibodies. Further included are uses and methods of treating conditions where inhibition of ABCB1-mediated efflux transport is desirable, such as, cancer or multi-drug resistance mediated by the ABCB1 transporter, e.g., multi-drug resistant cancer. In particular, the disclosure provides humanized multi-specific, e.g. bispecific, IgG (IgG1) antibodies that bind ABCB1 and a TAA. Multi-specific IgG1 antibody molecules are provided with Fc substitutions in at least one of a first and a second heavy chain constant region.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZBB19Avx1HV0cnYyVAAxnfxdPF2DeRhY0xJzilN5oTQ3g7Kba4izh25qQX58anFBYnJqXmpJvGOokYGRkYmhsaWJkaOhMXGqAO3YH1o</recordid><startdate>20240530</startdate><enddate>20240530</enddate><creator>PONATH, Paul David</creator><creator>O'CONNOR, Alissa Loren</creator><creator>ZHAI, Qianting</creator><creator>ARATHOON, William Robert</creator><creator>ABUHAY, Mastewal</creator><creator>BRIANTE, Raffaella</creator><creator>ZHANG, Pingping</creator><creator>TAN, Cindy</creator><scope>EVB</scope></search><sort><creationdate>20240530</creationdate><title>ANTI-ABCB1 ANTIBODIES</title><author>PONATH, Paul David ; O'CONNOR, Alissa Loren ; ZHAI, Qianting ; ARATHOON, William Robert ; ABUHAY, Mastewal ; BRIANTE, Raffaella ; ZHANG, Pingping ; TAN, Cindy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_AU2022413942A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2024</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>PONATH, Paul David</creatorcontrib><creatorcontrib>O'CONNOR, Alissa Loren</creatorcontrib><creatorcontrib>ZHAI, Qianting</creatorcontrib><creatorcontrib>ARATHOON, William Robert</creatorcontrib><creatorcontrib>ABUHAY, Mastewal</creatorcontrib><creatorcontrib>BRIANTE, Raffaella</creatorcontrib><creatorcontrib>ZHANG, Pingping</creatorcontrib><creatorcontrib>TAN, Cindy</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>PONATH, Paul David</au><au>O'CONNOR, Alissa Loren</au><au>ZHAI, Qianting</au><au>ARATHOON, William Robert</au><au>ABUHAY, Mastewal</au><au>BRIANTE, Raffaella</au><au>ZHANG, Pingping</au><au>TAN, Cindy</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ANTI-ABCB1 ANTIBODIES</title><date>2024-05-30</date><risdate>2024</risdate><abstract>Provided are anti-ABCB1 antibodies that may be used as multi-specific, including bispecific, antibodies targeting both ABCB1 and a tumor-associated antigen (TAA), as well as pharmaceutical compositions, nucleic acids, recombinant expression vectors, cells, and kits that include or encode such antibodies and multi-specific antibodies. Further included are uses and methods of treating conditions where inhibition of ABCB1-mediated efflux transport is desirable, such as, cancer or multi-drug resistance mediated by the ABCB1 transporter, e.g., multi-drug resistant cancer. In particular, the disclosure provides humanized multi-specific, e.g. bispecific, IgG (IgG1) antibodies that bind ABCB1 and a TAA. Multi-specific IgG1 antibody molecules are provided with Fc substitutions in at least one of a first and a second heavy chain constant region.</abstract><oa>free_for_read</oa></addata></record>
fulltext	fulltext_linktorsrc
identifier
ispartof
issn
language	eng
recordid	cdi_epo_espacenet_AU2022413942A1
source	esp@cenet
subjects	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title	ANTI-ABCB1 ANTIBODIES
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T23%3A14%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=PONATH,%20Paul%20David&rft.date=2024-05-30&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EAU2022413942A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true