CYTOTOXICITY TARGETING CHIMERAS
The present disclosure relates to heterobifunctional molecules, referred to as cytotoxicity targeting chimeras (CyTaCs) or antibody recruiting molecules (ARMs) that are able to simultaneously bind a target cell-surface protein as well as an exogenous antibody protein. The present disclosure also rel...
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| creator | TURUNEN, Brandon ZHANG, Cunyu PHELAN, James P OPLINGER, Jeffrey Alan KNAPP-REED, Beth A MARINO, JR LI, Yuehu MARCUS, Andrew Peter DODSON, Jason W SENDER, Matthew Robert LEACH, Craig DARCY, Michael Gerard CHEN, Peiling JEONG, Jae U YE, Guosen |
| description | The present disclosure relates to heterobifunctional molecules, referred to as cytotoxicity targeting chimeras (CyTaCs) or antibody recruiting molecules (ARMs) that are able to simultaneously bind a target cell-surface protein as well as an exogenous antibody protein. The present disclosure also relates to agents capable of binding to a receptor on a surface of a pathogenic cell and inducing the depletion of the pathogenic cell in a subject for use in the treatment of cancer, inflammatory diseases, autoimmune diseases, viral infection, or bacterial infection. |
| format | Patent |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | CYTOTOXICITY TARGETING CHIMERAS |
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