CYTOTOXICITY TARGETING CHIMERAS

The present disclosure relates to heterobifunctional molecules, referred to as cytotoxicity targeting chimeras (CyTaCs) or antibody recruiting molecules (ARMs) that are able to simultaneously bind a target cell-surface protein as well as an exogenous antibody protein. The present disclosure also rel...

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Bibliographische Detailangaben
Hauptverfasser:	TURUNEN, Brandon, ZHANG, Cunyu, PHELAN, James P, OPLINGER, Jeffrey Alan, KNAPP-REED, Beth A, MARINO, JR, LI, Yuehu, MARCUS, Andrew Peter, DODSON, Jason W, SENDER, Matthew Robert, LEACH, Craig, DARCY, Michael Gerard, CHEN, Peiling, JEONG, Jae U, YE, Guosen
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present disclosure relates to heterobifunctional molecules, referred to as cytotoxicity targeting chimeras (CyTaCs) or antibody recruiting molecules (ARMs) that are able to simultaneously bind a target cell-surface protein as well as an exogenous antibody protein. The present disclosure also relates to agents capable of binding to a receptor on a surface of a pathogenic cell and inducing the depletion of the pathogenic cell in a subject for use in the treatment of cancer, inflammatory diseases, autoimmune diseases, viral infection, or bacterial infection.