DOSAGE FORM FOR INTRA-ARTICULAR INJECTION COMPRISING COLCHICINE FOR USE IN THE TREATMENT OF CRYSTAL-AND NON-CRYSTAL ASSOCIATED ACUTE INFLAMMATORY ARTHRITIS

DOSAGE FORM FOR INTRA-ARTICULAR INJECTION COMPRISING COLCHICINE FOR USE IN THE TREATMENT OF CRYSTAL-AND NON-CRYSTAL ASSOCIATED ACUTE INFLAMMATORY ARTHRITIS

The present invention relates to pharmaceutical composition under the form of a suspension comprising controlled release microparticles comprising colchicine for use in the treatment of crystal-associated and non-crystal associated acute inflammatory arthritis by intra-articular injection into a joi...

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Hauptverfasser: SANSON, Charles, POULIQUEN, Gauthier, EA, Hang-Korng, HAYOZ, Daniel
Format: Patent
Sprache:eng
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator SANSON, Charles
POULIQUEN, Gauthier
EA, Hang-Korng
HAYOZ, Daniel
description The present invention relates to pharmaceutical composition under the form of a suspension comprising controlled release microparticles comprising colchicine for use in the treatment of crystal-associated and non-crystal associated acute inflammatory arthritis by intra-articular injection into a joint of said pharmaceutical composition, wherein the microparticles have a mean particle size greater than 10 pm, wherein the time required to release 80% by weight of the colchicine in the microparticles is greater than 1 day and may reach 15 days, wherein the colchicine is present in a concentration ranging from 2.5 to 2500 pg per ml of suspension and wherein the pharmaceutical composition has a volume ranging from 0.1 ml to 5 ml.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title DOSAGE FORM FOR INTRA-ARTICULAR INJECTION COMPRISING COLCHICINE FOR USE IN THE TREATMENT OF CRYSTAL-AND NON-CRYSTAL ASSOCIATED ACUTE INFLAMMATORY ARTHRITIS
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