VON WILLEBRAND FACTOR (VWF) INHIBITORS

The invention relates to inhibitors of Von Willebrand Factor (VWF), and particularly to anti-VWF antibodies. The invention extends to compositions comprising the inhibitors, including pharmaceutical compositions and kits. The invention also extends to methods of making and using the inhibitors, for...

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Bibliographische Detailangaben
Hauptverfasser: LEWIS, Alan, CLEMO, Nadine, MCKINNON, Tom
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The invention relates to inhibitors of Von Willebrand Factor (VWF), and particularly to anti-VWF antibodies. The invention extends to compositions comprising the inhibitors, including pharmaceutical compositions and kits. The invention also extends to methods of making and using the inhibitors, for example in therapy and diagnosis of conditions caused by platelet-mediated aggregation, including various cardiovascular diseases, such as acquired thrombotic thrombocytopenia purpura (aTTP), ischemic stroke and atherosclerosis.