PURIFICATION OF ANTIBODIES BY MIXED MODE CHROMATOGRAPHY
Herein is reported a method for producing or purifying an antibody using a mixed mode chromatography material that comprises ion exchange functional groups and hydrophobic interaction functional groups (MM HIC/IEX) operated in flowthrough mode, wherein the antibody is a hydrophilic antibody, and the...
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| Format: | Patent |
| Sprache: | eng |
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| Zusammenfassung: | Herein is reported a method for producing or purifying an antibody using a mixed mode chromatography material that comprises ion exchange functional groups and hydrophobic interaction functional groups (MM HIC/IEX) operated in flowthrough mode, wherein the antibody is a hydrophilic antibody, and the antibody is applied in a solution comprising the antibody and an antichaotropic salt to the MM HIC/IEX chromatography material. |
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