Inhibitors of cyclin-dependent kinase 7 (CDK7)
Thc present invention provides novel compounds of Fonnula (I) and pharmacutically acceptable salts, solvates, hydrates, tautorners, steroisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or pre...
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| creator | MALOJCIC, Goran WHITMORE, Kenneth Matthew CIBLAT, Stephane SINKO, William PIRAS, Henri SCHMIDT, Darby WINTER, Dana K ZAHLER, Robert CHUAQUI, Claudio KABRO, Anzhelika LUND, Kate-Lyn ROY, Stephanie SPROTT, Kevin MARINEAU, Jason J |
| description | Thc present invention provides novel compounds of Fonnula (I) and pharmacutically acceptable salts, solvates, hydrates, tautorners, steroisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of cyclin-dependent kinase 7 (CDK7), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject. |
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Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of cyclin-dependent kinase 7 (CDK7), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240627&DB=EPODOC&CC=AU&NR=2022246416B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240627&DB=EPODOC&CC=AU&NR=2022246416B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MALOJCIC, Goran</creatorcontrib><creatorcontrib>WHITMORE, Kenneth Matthew</creatorcontrib><creatorcontrib>CIBLAT, Stephane</creatorcontrib><creatorcontrib>SINKO, William</creatorcontrib><creatorcontrib>PIRAS, Henri</creatorcontrib><creatorcontrib>SCHMIDT, Darby</creatorcontrib><creatorcontrib>WINTER, Dana K</creatorcontrib><creatorcontrib>ZAHLER, Robert</creatorcontrib><creatorcontrib>CHUAQUI, Claudio</creatorcontrib><creatorcontrib>KABRO, Anzhelika</creatorcontrib><creatorcontrib>LUND, Kate-Lyn</creatorcontrib><creatorcontrib>ROY, Stephanie</creatorcontrib><creatorcontrib>SPROTT, Kevin</creatorcontrib><creatorcontrib>MARINEAU, Jason J</creatorcontrib><title>Inhibitors of cyclin-dependent kinase 7 (CDK7)</title><description>Thc present invention provides novel compounds of Fonnula (I) and pharmacutically acceptable salts, solvates, hydrates, tautorners, steroisomers, isotopically labeled derivatives, and compositions thereof. 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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Inhibitors of cyclin-dependent kinase 7 (CDK7) |
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