Novel 6-6 bicyclic aromatic ring substituted nucleoside analogues for use as PRMT5 inhibitors

The present invention relates novel 6-6 bicyclic aromatic ring substituted nucleoside analogues of Formula (I) Ar-Z Het (I) 5 wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates t...

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Bibliographische Detailangaben

Hauptverfasser:	BREHMER, Dirk, VIELLEVOYE, Marcel, MEERPOEL, Lieven, THURING, Johannes Wilhelmus John F, SUN, Weimei, BEKE, Lijs, WU, Tongfei, PANDE, Vineet, PARADE, Marcus Cornelis Bernardus Catharina, DIELS, Gaston Stanislas Marcella, BOECKX, An, LAWSON, Edward Charles, GILISSEN, Ronaldus Arnodus Hendrika Joseph, SCHEPENS, Wim Bert Griet
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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