Heteroaryl derivative, method for producing the same, and pharmaceutical composition comprising same as effective component

Heteroaryl derivative, method for producing the same, and pharmaceutical composition comprising same as effective component

Abstract The present invention relates to a 6-(isooxazolidin-2-yl)-N-phenylpyrimidin-4-amine derivative, and a pharmaceutical composition for preventing or treating cancer comprising the compound as an effective component. The compound exhibits high inhibitory activity against an epidermal growth fa...

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Bibliographische Detailangaben
Hauptverfasser: Kim, Hwan, Kim, Nam Doo, Han, Ah Reum, Ko, Yi Kyung, Hwang, Dong Keun, Lee, Sun Hwa, Kang, Se In, Lee, Youn Ho, Seok, Ji Yoon, Kim, Da Eun, Choi, Hwan Geun, Son, Jung Beom, Kim, Seung Su, Ryu, Min Seok, Ko, Eun Hwa, Kang, Ju Hee
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Abstract The present invention relates to a 6-(isooxazolidin-2-yl)-N-phenylpyrimidin-4-amine derivative, and a pharmaceutical composition for preventing or treating cancer comprising the compound as an effective component. The compound exhibits high inhibitory activity against an epidermal growth factor receptor (EGFR) variant, or wild-type or variants of one or more of ERBB2 and ERBB4, and thus may be usefully used in the treatment of cancers in which same are expressed. In particular, the compound exhibits excellent inhibitory activity on proliferation of lung cancer cell lines, and thus can be usefully used in the treatment of lung cancer.