HETEROTANDEM BICYCLIC PEPTIDE COMPLEXES

The present invention relates to heterotandem bicyclic peptide complexes which comprise a first peptide ligand, which binds to a component present on a cancer cell, conjugated via a linker to one or more second peptide ligands, which bind to one or more components present on a natural killer (NK) ce...

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Hauptverfasser: BRANDISH, Phil, DUFORT, Fay, UHLENBROICH, Sandra, MCDONNELL, Kevin, REPASH, Liz, KEEN, Nicholas, GAYNOR, Katie, CHEN, Liuhong, MUDD, Gemma, LEITHEISER, Chris
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creator BRANDISH, Phil
DUFORT, Fay
UHLENBROICH, Sandra
MCDONNELL, Kevin
REPASH, Liz
KEEN, Nicholas
GAYNOR, Katie
CHEN, Liuhong
MUDD, Gemma
LEITHEISER, Chris
description The present invention relates to heterotandem bicyclic peptide complexes which comprise a first peptide ligand, which binds to a component present on a cancer cell, conjugated via a linker to one or more second peptide ligands, which bind to one or more components present on a natural killer (NK) cell. The invention also relates to the use of said heterotandem bicyclic peptide complexes in preventing, suppressing or treating cancer.
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subjects CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title HETEROTANDEM BICYCLIC PEPTIDE COMPLEXES
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