Fused bicyclic sGC stimulators
The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutical formulations comprising them and their uses thereof, alone or in combination with one or more additional agents, for treating various diseases, wherein an increase in the concentration of nitric oxide (N...
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| creator | NAKAI, Takashi TANG, Kim GERMANO, Peter RENHOWE, Paul Allan JUNG, Joon LEE, Thomas Wai-Ho MERMERIAN, Ara IYER, Karthik IYENGAR, Rajesh R JIA, Lei IM, G-Yoon Jamie RENNIE, Glen Robert BARDEN, Timothy Claude |
| description | The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutical formulations comprising them and their uses thereof, alone or in combination with one or more additional agents, for treating various diseases, wherein an increase in the concentration of nitric oxide (NO) or an increase in the concentration of cyclic Guanosine Monophosphate (cGMP), or both, or an upregulation of the NO pathway is desirable. The compounds are of Formula I: G:---Z (JC) X y-:--X (R10)q -JN (j B)n Formula I. 18602866_1 (GHMatters) P110713.AU.1 |
| format | Patent |
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The compounds are of Formula I: G:---Z (JC) X y-:--X (R10)q -JN (j B)n Formula I. 18602866_1 (GHMatters) P110713.AU.1</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Fused bicyclic sGC stimulators |
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