METHODS FOR ENHANCING THERAPEUTIC EFFICACY OF ISOLATED CELLS FOR CELL THERAPY

This disclosure relates to methods for enhancing the therapeutic efficacy of isolated cells for use in cell therapies such as adoptive cell transfer therapies by insertion of an under¬ expressed miRNA that is beneficial for therapeutic efficacy of cell therapies into the actively expressed locus of...

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Bibliographische Detailangaben
Hauptverfasser:	FEINSTEIN, Elena, ZURR, Daniel, KALINSKI, Hagar
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	This disclosure relates to methods for enhancing the therapeutic efficacy of isolated cells for use in cell therapies such as adoptive cell transfer therapies by insertion of an under¬ expressed miRNA that is beneficial for therapeutic efficacy of cell therapies into the actively expressed locus of a gene, either protein coding or non-coding, that hampers therapeutic efficacy of cell therapies by this disrupting expression of the latter while inducing expression of the former.