TARGETING ENHANCER RNAS FOR THE TREATMENT OF PRIMARY BRAIN TUMORS

TARGETING ENHANCER RNAS FOR THE TREATMENT OF PRIMARY BRAIN TUMORS

The invention provides enhancer RNAs (eRNAs) that are expressed specifically in glioma stem cells and whose expression correlates with decreased survival of patients with glioblastomas. The eRNAs are selected, for example, from eTMEMSSb, eRTP5, or eNINJ1l The invention also provides an RNA therapy t...

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Hauptverfasser: TAPINOS, Nikolaos, AKOBUNDU, Blessing
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Sprache:eng
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator TAPINOS, Nikolaos
AKOBUNDU, Blessing
description The invention provides enhancer RNAs (eRNAs) that are expressed specifically in glioma stem cells and whose expression correlates with decreased survival of patients with glioblastomas. The eRNAs are selected, for example, from eTMEMSSb, eRTP5, or eNINJ1l The invention also provides an RNA therapy that targets glioma stem cell eRNAs using synthetic oligonucleotides that knock out the eRNA expression. The invention further provides viral vectors that deliver shRNA that inhibit the expression of the eRNA.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title TARGETING ENHANCER RNAS FOR THE TREATMENT OF PRIMARY BRAIN TUMORS
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