Method of treating an autoimmune disease with antagonistic CD40 monoclonal antibodies

A method of treating an autoimmune disease such as Sjögren's Syndrome is provided. The method comprises administration of an antibody or an antigen binding portion thereof that specifically binds an epitope of CD40 associated with antagonism. The antibody or the antigen binding portion thereof...

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Hauptverfasser: YE, Ying, FURA, Aberra, STRUTHERS, Mary, SHARDA, Nidhi, GIRGIS, Ihab, PRICE, Karen, ARAS, Urvi
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creator YE, Ying
FURA, Aberra
STRUTHERS, Mary
SHARDA, Nidhi
GIRGIS, Ihab
PRICE, Karen
ARAS, Urvi
description A method of treating an autoimmune disease such as Sjögren's Syndrome is provided. The method comprises administration of an antibody or an antigen binding portion thereof that specifically binds an epitope of CD40 associated with antagonism. The antibody or the antigen binding portion thereof does not exhibit CD40 agonist activity in either
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subjects CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Method of treating an autoimmune disease with antagonistic CD40 monoclonal antibodies
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