Compositions and methods for treating or preventing hereditary angioedema

Described herein are compositions and methods for treating a subject having or at risk of developing hereditary angioedema. Using the compositions and methods of the disclosure a patient may be provided one or more agents that elevate the expression and/or activity levels of C1 -esterase inhibitor (...

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Hauptverfasser: WOLFE, Jia L, MARKS-BLUTH, Jonathon Simeon, GASPAR, Bobby, SAGOO, Pervinder, LEMOINE, Adrien, PENNUCCI, Valentina
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creator WOLFE, Jia L
MARKS-BLUTH, Jonathon Simeon
GASPAR, Bobby
SAGOO, Pervinder
LEMOINE, Adrien
PENNUCCI, Valentina
description Described herein are compositions and methods for treating a subject having or at risk of developing hereditary angioedema. Using the compositions and methods of the disclosure a patient may be provided one or more agents that elevate the expression and/or activity levels of C1 -esterase inhibitor (C1-INH). Exemplary agents that may be used in conjunction with the compositions and methods of the disclosure for this purpose include cells, such as pluripotent cells, that express C1- INH.
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subjects BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
title Compositions and methods for treating or preventing hereditary angioedema
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