Tricyclic pyrimidinone compound, preparation method therefor, and composition and use thereof

A tricyclic pyrimidinone compound as shown in formula (I) or a tautomer, a mesomer, a raceme, an enantiomer, or a diastereoisomer thereof, or a form of a mixture thereof, or a pharmaceutically acceptable salt thereof, wherein same has the structure as shown in formula (I), is a completely new Lp-PLA...

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Bibliographische Detailangaben
Hauptverfasser:	WANG, Dongqin, GU, Zhenghua, HU, Youhong
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	A tricyclic pyrimidinone compound as shown in formula (I) or a tautomer, a mesomer, a raceme, an enantiomer, or a diastereoisomer thereof, or a form of a mixture thereof, or a pharmaceutically acceptable salt thereof, wherein same has the structure as shown in formula (I), is a completely new Lp-PLA2 inhibitor, and can be used for treating neurodegenerative-related diseases, such as Alzheimer's disease (AD), glaucoma, age-related macular degeneration (AMD), or cardiovascular diseases including atherosclerosis, etc.