Injectable composition comprising GnRH analogue

Injectable composition comprising GnRH analogue

An injectable composition of the present invention has remarkably increased safety by forming, into a composition, a sorbitan unsaturated fatty acid ester having a polar head with two or more -OH (hydroxyl) groups, is in a liquid phase in a phase where an aqueous fluid is absent so as to be easily a...

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Hauptverfasser: NOH, Sang Myoung, LIM, Jong Lae, JUNG, Sung Bum, KO, Jin Young
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Sprache:eng
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator NOH, Sang Myoung
LIM, Jong Lae
JUNG, Sung Bum
KO, Jin Young
description An injectable composition of the present invention has remarkably increased safety by forming, into a composition, a sorbitan unsaturated fatty acid ester having a polar head with two or more -OH (hydroxyl) groups, is in a liquid phase in a phase where an aqueous fluid is absent so as to be easily applied to pharmaceutical preparations in dosage forms, and forms a liquid crystal in an aqueous fluid phase so that sustained-release effects of GnRH derivatives, which are used as a pharmaceutically active ingredient in vivo, are exhibited. In addition, in an injectable composition of the present invention, a sustained-release lipid pre-concentrate comprising GnRH derivatives includes water, and thus a liquid injectable agent forms a liquid crystal gel immediately after administration, so that the effects of reducing initial release rate and remarkably increasing sustained-release properties of the drug are exhibited.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Injectable composition comprising GnRH analogue
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