Compounds and compositions for inhibiting the activity of HIF2alpha and their methods of use

Compounds and compositions for inhibiting the activity of HIF2alpha and their methods of use

The present invention relates to compounds of formula (I) or a pharmaceutically acceptable salt form thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to the use of...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: LANGLOIS, Jean-Baptiste Georges Armand, NIETO-OBERHUBER, Cristina Montserrat, WILCKEN, Rainer, LI, Tengfei, GERSPACHER, Marc, WARIN, Nicolas, LORTHIOIS, Edwige Liliane Jeanne, VAUPEL, Andrea, FRITSCH, Christine, MURA, Christophe, FAIRHURST, Robin Alec, TODOROV, Milen, HINRICHS, Jürgen Hans-Hermann, LEBLANC, Catherine
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention relates to compounds of formula (I) or a pharmaceutically acceptable salt form thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to the use of the compounds in the treatment of disease. The compounds are inhibitors or modulators of HIF2alpha.