Novel polypeptides with improved proteolytic stability, and methods of preparing and using same
The present invention includes methods of improving proteolytic stability of a polypeptide, comprising alkylating at least one selected from the group consisting of a N 5 terminus amino group, the NH group of the N-terminus first internal amide bond, another primary amino group, a thiol group and a...
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| creator | KUMAR, Krishna RAMAN, Venkata MONTANARI, Vittorio BEINBORN, Martin |
| description | The present invention includes methods of improving proteolytic stability of a polypeptide, comprising alkylating at least one selected from the group consisting of a N 5 terminus amino group, the NH group of the N-terminus first internal amide bond, another primary amino group, a thiol group and a thioether group within the polypeptide. The present invention further includes polypeptides incorporating such chemical modifications. 18204370_1 (GHMatters) P108672AU.1 |
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The present invention further includes polypeptides incorporating such chemical modifications. 18204370_1 (GHMatters) P108672AU.1</description><language>eng</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240328&DB=EPODOC&CC=AU&NR=2021258060B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240328&DB=EPODOC&CC=AU&NR=2021258060B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KUMAR, Krishna</creatorcontrib><creatorcontrib>RAMAN, Venkata</creatorcontrib><creatorcontrib>MONTANARI, Vittorio</creatorcontrib><creatorcontrib>BEINBORN, Martin</creatorcontrib><title>Novel polypeptides with improved proteolytic stability, and methods of preparing and using same</title><description>The present invention includes methods of improving proteolytic stability of a polypeptide, comprising alkylating at least one selected from the group consisting of a N 5 terminus amino group, the NH group of the N-terminus first internal amide bond, another primary amino group, a thiol group and a thioether group within the polypeptide. The present invention further includes polypeptides incorporating such chemical modifications. 18204370_1 (GHMatters) P108672AU.1</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNijEKwkAQANNYiPqHLSwV4onB1ohiZaV1OHMbs3CXW7Krkt97ig-wmoGZcVad4xM9cPQDIys5FHiRtkCB-5QcJCimrFSDqL2RJx0WYDsHAbWNTiA26UK2PXX3b3jIx8QGnGajxnrB2Y-TbH48XPanJXKsUNjW2KFWu6vJzcpstnmRl6VZ_7m9AWA9Pt4</recordid><startdate>20240328</startdate><enddate>20240328</enddate><creator>KUMAR, Krishna</creator><creator>RAMAN, Venkata</creator><creator>MONTANARI, Vittorio</creator><creator>BEINBORN, Martin</creator><scope>EVB</scope></search><sort><creationdate>20240328</creationdate><title>Novel polypeptides with improved proteolytic stability, and methods of preparing and using same</title><author>KUMAR, Krishna ; RAMAN, Venkata ; MONTANARI, Vittorio ; BEINBORN, Martin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_AU2021258060BB23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2024</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>KUMAR, Krishna</creatorcontrib><creatorcontrib>RAMAN, Venkata</creatorcontrib><creatorcontrib>MONTANARI, Vittorio</creatorcontrib><creatorcontrib>BEINBORN, Martin</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KUMAR, Krishna</au><au>RAMAN, Venkata</au><au>MONTANARI, Vittorio</au><au>BEINBORN, Martin</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Novel polypeptides with improved proteolytic stability, and methods of preparing and using same</title><date>2024-03-28</date><risdate>2024</risdate><abstract>The present invention includes methods of improving proteolytic stability of a polypeptide, comprising alkylating at least one selected from the group consisting of a N 5 terminus amino group, the NH group of the N-terminus first internal amide bond, another primary amino group, a thiol group and a thioether group within the polypeptide. The present invention further includes polypeptides incorporating such chemical modifications. 18204370_1 (GHMatters) P108672AU.1</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Novel polypeptides with improved proteolytic stability, and methods of preparing and using same |
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