Alpha-hydroxylated fatty-acid metabolites, medical uses of same and use as biomarkers

Described are fatty acids with one or more unsaturations, having an odd hydrocarbon chain, the fatty acids having the chemical structure of the therapeutically active metabolites of even-chain mono- or polyunsaturated alpha-hydroxylated fatty acids. Also described are compositions comprising said fa...

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Hauptverfasser: ESCRIBÁ RUIZ, Pablo Vicente, FERNÁNDEZ GARCÍA, Paula, BETETA GOBEL, Roberto, CABOT BAUZÁ, Juan, ARBONA GONZÁLEZ, Laura, LLADÓ CAÑELLAS, Victoria, ROSSELLÓ CASTILLO, Catalina Ana, BUSQUETS XAUBET, Xavier, PARETS BARRIOS, Sebastià, MILLARES PIZÀ, Marc, RODRÍGUEZ LORCA, Raquel, CANO URREGO, Emilce, TORRES CANALEJO, Manuel
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Sprache:eng
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Zusammenfassung:Described are fatty acids with one or more unsaturations, having an odd hydrocarbon chain, the fatty acids having the chemical structure of the therapeutically active metabolites of even-chain mono- or polyunsaturated alpha-hydroxylated fatty acids. Also described are compositions comprising said fatty acids, medical uses thereof, and the use thereof as indicators of the efficacy of and/or response to the treatment of a patient with the even-chain mono- or polyunsaturated alpha-hydroxylated fatty acids from which they are derived.