Inkjet deposition of reagents for histological samples

Inkjet deposition of reagents for histological samples

Devices and methods for the deposition of reagent droplets onto cells or tissue samples are disclosed. Optionally the samples have a protective fluid layer, the droplets have volumes between about 1 pL and about 50 pL, a pH modifier is dispensed to the samples, the 5 droplets have a velocity of betw...

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Hauptverfasser: KOZIKOWSKI, Raymond, GROLL, Henning, THAKUR, Raviraj, PALUSZCYK, Chana, KLEIN, Eric, HAZAR, Melis, POLASKE, Mindy
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INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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creator KOZIKOWSKI, Raymond
GROLL, Henning
THAKUR, Raviraj
PALUSZCYK, Chana
KLEIN, Eric
HAZAR, Melis
POLASKE, Mindy
description Devices and methods for the deposition of reagent droplets onto cells or tissue samples are disclosed. Optionally the samples have a protective fluid layer, the droplets have volumes between about 1 pL and about 50 pL, a pH modifier is dispensed to the samples, the 5 droplets have a velocity of between about 5 m/s to about 15 m/s, the droplets have a kinetic energy of greater than 9.52x10-m Joules, and the spatial density of reagents deposited on the 6 samples ranges from about 50 dpi to about 1200 dpi. Also disclosed are reagent compositions suitable for dispensing via a droplet-on-demand system, whereby the reagent composition is selected from the group consisting of a primary stain reagent composition, 10 an antibody reagent composition and a large molecule staining composition. Also an inkjet deposition system and means for imaging a slide containing a sample are disclosed.
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subjects INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
title Inkjet deposition of reagents for histological samples
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