Heterocyclic compounds as Delta-5 Desaturase inhibitors and methods of use
The present disclosure provides compounds useful for the inhibition of Delta-5 Desaturase ("D5D"). The compounds have a general Formula (I): wherein the variables of Formula (I) are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of...
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| creator | SIEGMUND, Aaron C AMEGADZIE, Albert POZZAN, Alfonso REEVES, Corey BOURBEAU, Matthew P MINATTI, Ana E TASSINI, Sabrina ALLEN, Jennifer R TONELLI, Federica MA, Vu Van LATTANZI, Giulia WALTON, Mary GOODMAN, Clifford LINGARD, Iain CHEN, Ning LIU, Qingyian LOW, Jonathan D |
| description | The present disclosure provides compounds useful for the inhibition of Delta-5 Desaturase ("D5D"). The compounds have a general Formula (I): wherein the variables of Formula (I) are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a metabolic or cardiovascular disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I). |
| format | Patent |
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The compounds have a general Formula (I): wherein the variables of Formula (I) are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a metabolic or cardiovascular disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I).</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220609&DB=EPODOC&CC=AU&NR=2020391161A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220609&DB=EPODOC&CC=AU&NR=2020391161A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SIEGMUND, Aaron C</creatorcontrib><creatorcontrib>AMEGADZIE, Albert</creatorcontrib><creatorcontrib>POZZAN, Alfonso</creatorcontrib><creatorcontrib>REEVES, Corey</creatorcontrib><creatorcontrib>BOURBEAU, Matthew P</creatorcontrib><creatorcontrib>MINATTI, Ana E</creatorcontrib><creatorcontrib>TASSINI, Sabrina</creatorcontrib><creatorcontrib>ALLEN, Jennifer R</creatorcontrib><creatorcontrib>TONELLI, Federica</creatorcontrib><creatorcontrib>MA, Vu Van</creatorcontrib><creatorcontrib>LATTANZI, Giulia</creatorcontrib><creatorcontrib>WALTON, Mary</creatorcontrib><creatorcontrib>GOODMAN, Clifford</creatorcontrib><creatorcontrib>LINGARD, Iain</creatorcontrib><creatorcontrib>CHEN, Ning</creatorcontrib><creatorcontrib>LIU, Qingyian</creatorcontrib><creatorcontrib>LOW, Jonathan D</creatorcontrib><title>Heterocyclic compounds as Delta-5 Desaturase inhibitors and methods of use</title><description>The present disclosure provides compounds useful for the inhibition of Delta-5 Desaturase ("D5D"). The compounds have a general Formula (I): wherein the variables of Formula (I) are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a metabolic or cardiovascular disorder. 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The compounds have a general Formula (I): wherein the variables of Formula (I) are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a metabolic or cardiovascular disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I).</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Heterocyclic compounds as Delta-5 Desaturase inhibitors and methods of use |
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