Heterocyclic compounds as Delta-5 Desaturase inhibitors and methods of use

The present disclosure provides compounds useful for the inhibition of Delta-5 Desaturase ("D5D"). The compounds have a general Formula (I): wherein the variables of Formula (I) are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of...

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Bibliographische Detailangaben
Hauptverfasser:	SIEGMUND, Aaron C, AMEGADZIE, Albert, POZZAN, Alfonso, REEVES, Corey, BOURBEAU, Matthew P, MINATTI, Ana E, TASSINI, Sabrina, ALLEN, Jennifer R, TONELLI, Federica, MA, Vu Van, LATTANZI, Giulia, WALTON, Mary, GOODMAN, Clifford, LINGARD, Iain, CHEN, Ning, LIU, Qingyian, LOW, Jonathan D
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present disclosure provides compounds useful for the inhibition of Delta-5 Desaturase ("D5D"). The compounds have a general Formula (I): wherein the variables of Formula (I) are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a metabolic or cardiovascular disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I).