Balloon catheter systems for delivery of dry drug delivery vesicles to a vessel in the body

BALLOON CATHETER SYSTEMS FOR DELIVERY OF DRY DRUG DELIVERY VESICLES TO A VESSEL IN THE BODY A method for delivery of drugs or therapeutic agents to a vessel within a body of a patient, said method comprising the steps of: providing a catheter system comprising: a balloon catheter comprising a cathet...

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Hauptverfasser: BURGERMEISTER, Robert, BAUMBACH, William R, SHERMAN, Darren R
Format: Patent
Sprache:eng
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Zusammenfassung:BALLOON CATHETER SYSTEMS FOR DELIVERY OF DRY DRUG DELIVERY VESICLES TO A VESSEL IN THE BODY A method for delivery of drugs or therapeutic agents to a vessel within a body of a patient, said method comprising the steps of: providing a catheter system comprising: a balloon catheter comprising a catheter body with a distal end adapted for insertion into vasculature of a patient, a porous balloon disposed on the distal end, a proximal end adapted for connection to a fluid source, and a lumen extending from the proximal end to the balloon; a storage chamber with a reservoir of dry drug delivery vesicles; an inflator; a suspension chamber with a connector for fluid communication with the inflator; wherein said suspension chamber comprises a cylinder divided into a first cylinder chamber and a second cylinder chamber, reconstituting the drug delivery vesicles by forcing fluid into the storage chamber to reconstitute the drug delivery vesicles in the storage chamber and create a suspension of reconstituted drug delivery vesicles; drawing the suspension of reconstituted drug delivery vesicles into the first cylinder chamber; aligning the first cylinder chamber with the lumen of the catheter; aligning the inflator with the second cylinder chamber and operating the inflator to force fluid into the second cylinder chamber, to thereby force the suspension of reconstituted drug delivery vesicles from the first cylinder chamber into the catheter, thereby forcing the suspension of reconstituted drug delivery vesicles through a wall of the balloon and into body tissue surrounding the balloon.