Formulation for oral delivery of proteins, peptides and small molecules with poor permeability

The present disclosure is directed to a pharmaceutical formulation intended for oral delivery of synthetic or natural poorly permeable calcitonin gene-related peptide (CGRP) inhibitors or salts/solvates thereof having a therapeutic activity. The pharmaceutical formulation can include a synthetic or...

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Hauptverfasser: PLASSAT, Vincent, POINTEAUX, Thomas, CONWAY, Charles M, MEISSONNIER, Julien, DUBOWCHIK, Gene M, GALUS, Aurélia, HILBOLD, Benoit
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creator PLASSAT, Vincent
POINTEAUX, Thomas
CONWAY, Charles M
MEISSONNIER, Julien
DUBOWCHIK, Gene M
GALUS, Aurélia
HILBOLD, Benoit
description The present disclosure is directed to a pharmaceutical formulation intended for oral delivery of synthetic or natural poorly permeable calcitonin gene-related peptide (CGRP) inhibitors or salts/solvates thereof having a therapeutic activity. The pharmaceutical formulation can include a synthetic or natural poorly permeable CGRP inhibitors or salt or solvate thereof in an amount 0.01-10 wt.% of the total weight of the formulation; a lipophilic phase comprising triglycerides of fatty acids in an amount of 50-80 wt.% of the total weight of the formulation; and at least one lipophilic surfactant comprising partial esters of polyol and fatty acids in an amount of about 10-50 wt.% of the total weight of the formulation.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title Formulation for oral delivery of proteins, peptides and small molecules with poor permeability
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