Use of anatabine to treat inflammation and methods of synthesizing anatabine

Use of anatabine to treat inflammation and methods of synthesizing anatabine

Pharmaceutical compositions comprising an isolated form of anatabine or a salt thereof can be used to treat disorders comprising an inflammatory component, including chronic, low level inflammation. In another aspect, methods for the synthetic preparation of anatabine involve reacting benzophenoneim...

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Hauptverfasser: PUTHIAPARAMPIL, Tom Thomas, DAVID, Thomas Kanathkunn, WILLIAMS, Jonnie R, RAJU, Muppala Sarveswara
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator PUTHIAPARAMPIL, Tom Thomas
DAVID, Thomas Kanathkunn
WILLIAMS, Jonnie R
RAJU, Muppala Sarveswara
description Pharmaceutical compositions comprising an isolated form of anatabine or a salt thereof can be used to treat disorders comprising an inflammatory component, including chronic, low level inflammation. In another aspect, methods for the synthetic preparation of anatabine involve reacting benzophenoneimine with 3-aminomethyl pyridine to form benzylhydrylidene pyridin-3-yl-methyl-amine. The benzylhydrylidene-pyridin-3-yl-methyl-amine is treated with a non-nucleophilic base and a dielectrophile, such as cis-1,4-dichloro-2-butene, followed by acidification, then basification, to provide anatabine.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Use of anatabine to treat inflammation and methods of synthesizing anatabine
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