USE OF CHIMERIC ANTIGEN RECEPTOR-MODIFIED T CELLS TO TREAT CANCER

The present invention provides genetically modified T cells in compositions and methods for treating cancer in a human. The invention includes administering a chimeric antigen receptor (CAR) that genetically modifies T cell to express the CAR. The CAR comprises an antigen binding domain, a transmemb...

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Bibliographische Detailangaben
Hauptverfasser:	Milone, Michael C, Porter, David L, Levine, Bruce L, June, Carl H, Kalos, Michael D
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
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Beschreibung
Zusammenfassung:	The present invention provides genetically modified T cells in compositions and methods for treating cancer in a human. The invention includes administering a chimeric antigen receptor (CAR) that genetically modifies T cell to express the CAR. The CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signalling region, and a CD3 zeta signalling domain.